The association of Helicobacter pylori infection with serum lipid profiles: An evaluation based on a combination of meta-analysis and a propensity score-based observational approach
Autor: | Kenta Gondo, Nobutake Yamamichi, Chihiro Takeuchi, Ryoichi Wada, Yu Takahashi, Toru Mitsushima, Takeshi Shimamoto, Kazuhiko Koike |
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Rok vydání: | 2020 |
Předmět: |
Male
Bacterial Diseases Multivariate analysis 030204 cardiovascular system & hematology Pathology and Laboratory Medicine Gastroenterology Biochemistry chemistry.chemical_compound 0302 clinical medicine Mathematical and Statistical Techniques Japan Risk Factors Helicobacter Epidemiology Medicine and Health Sciences 030212 general & internal medicine Aged 80 and over Multidisciplinary medicine.diagnostic_test biology Statistics Middle Aged Metaanalysis Lipids Lipid Profiles Bacterial Pathogens Infectious Diseases Cholesterol Medical Microbiology Meta-analysis Physical Sciences Medicine Female Pathogens Research Article Adult medicine.medical_specialty Science Lipoproteins Research and Analysis Methods Microbiology Helicobacter Infections 03 medical and health sciences Young Adult Meta-Analysis as Topic Internal medicine medicine Humans Statistical Methods Propensity Score Microbial Pathogens Triglycerides Aged Dyslipidemias Triglyceride Helicobacter pylori Bacteria business.industry Cholesterol HDL Organisms Biology and Life Sciences Proteins Cholesterol LDL biology.organism_classification Confidence interval Helicobacter Pylori Infection chemistry Multivariate Analysis Lipid profile business Mathematics |
Zdroj: | PLoS ONE PLoS ONE, Vol 15, Iss 6, p e0234433 (2020) |
ISSN: | 1932-6203 |
Popis: | BackgroundSeveral previous studies have suggested that Helicobacter pylori (H. pylori) infection affects the serum lipid profile. However, it remains controversial and the mechanism has not been elucidated. The purpose of this study is to use an epidemiological perspective to evaluate the association between H. pylori infection and the serum lipid profile.MethodsMultivariate analysis was performed using the data of serum lipid profile, infection status of H. pylori, fitness/lifestyle habits, and various subjects' characteristics which were derived from the 15,679 generally healthy individuals in Japan. The average treatment effects (ATEs) of H. pylori infection on the serum lipid profile were estimated using augmented inverse probability weighting (AIPW). A meta-analysis was also performed using the 27 studies worldwide in which the status of H. pylori infection and at least one serum examination value (high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), or triglyceride (TG)) were described.ResultsThe ATEs determined with AIPW showed that H. pylori infection has significant positive effects on LDL-C and TC (ATE (95% confidence interval [95%CI]) = 3.4 (2.36-4.49) and 1.7 (0.58-2.88), respectively) but has significant negative effects on HDL-C and TG (ATE (95%CI) = -1.2 (-1.74 to -0.72) and -3.5 (-5.92 to -1.06), respectively). The meta-analysis to estimate the association between H. pylori infection and the serum lipid profile revealed that H. pylori infection is positively associated with LDL-C, TC, and TG (standardized mean difference [SMD] (95%CI) = 0.11 (0.09-0.12), 0.09 (0.07-0.10) and 0.06 (0.05-0.08), respectively) and negatively associated with HDL-C (SMD = -0.13 (-0.14 to -0.12)).ConclusionBoth our multivariate analyses and meta-analysis showed that H. pylori infection significantly affects the serum lipid profile, which might lead to various dyslipidemia-induced severe diseases like coronary thrombosis or cerebral infarction. |
Databáze: | OpenAIRE |
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