The association of Helicobacter pylori infection with serum lipid profiles: An evaluation based on a combination of meta-analysis and a propensity score-based observational approach

Autor: Kenta Gondo, Nobutake Yamamichi, Chihiro Takeuchi, Ryoichi Wada, Yu Takahashi, Toru Mitsushima, Takeshi Shimamoto, Kazuhiko Koike
Rok vydání: 2020
Předmět:
Male
Bacterial Diseases
Multivariate analysis
030204 cardiovascular system & hematology
Pathology and Laboratory Medicine
Gastroenterology
Biochemistry
chemistry.chemical_compound
0302 clinical medicine
Mathematical and Statistical Techniques
Japan
Risk Factors
Helicobacter
Epidemiology
Medicine and Health Sciences
030212 general & internal medicine
Aged
80 and over
Multidisciplinary
medicine.diagnostic_test
biology
Statistics
Middle Aged
Metaanalysis
Lipids
Lipid Profiles
Bacterial Pathogens
Infectious Diseases
Cholesterol
Medical Microbiology
Meta-analysis
Physical Sciences
Medicine
Female
Pathogens
Research Article
Adult
medicine.medical_specialty
Science
Lipoproteins
Research and Analysis Methods
Microbiology
Helicobacter Infections
03 medical and health sciences
Young Adult
Meta-Analysis as Topic
Internal medicine
medicine
Humans
Statistical Methods
Propensity Score
Microbial Pathogens
Triglycerides
Aged
Dyslipidemias
Triglyceride
Helicobacter pylori
Bacteria
business.industry
Cholesterol
HDL
Organisms
Biology and Life Sciences
Proteins
Cholesterol
LDL
biology.organism_classification
Confidence interval
Helicobacter Pylori Infection
chemistry
Multivariate Analysis
Lipid profile
business
Mathematics
Zdroj: PLoS ONE
PLoS ONE, Vol 15, Iss 6, p e0234433 (2020)
ISSN: 1932-6203
Popis: BackgroundSeveral previous studies have suggested that Helicobacter pylori (H. pylori) infection affects the serum lipid profile. However, it remains controversial and the mechanism has not been elucidated. The purpose of this study is to use an epidemiological perspective to evaluate the association between H. pylori infection and the serum lipid profile.MethodsMultivariate analysis was performed using the data of serum lipid profile, infection status of H. pylori, fitness/lifestyle habits, and various subjects' characteristics which were derived from the 15,679 generally healthy individuals in Japan. The average treatment effects (ATEs) of H. pylori infection on the serum lipid profile were estimated using augmented inverse probability weighting (AIPW). A meta-analysis was also performed using the 27 studies worldwide in which the status of H. pylori infection and at least one serum examination value (high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), or triglyceride (TG)) were described.ResultsThe ATEs determined with AIPW showed that H. pylori infection has significant positive effects on LDL-C and TC (ATE (95% confidence interval [95%CI]) = 3.4 (2.36-4.49) and 1.7 (0.58-2.88), respectively) but has significant negative effects on HDL-C and TG (ATE (95%CI) = -1.2 (-1.74 to -0.72) and -3.5 (-5.92 to -1.06), respectively). The meta-analysis to estimate the association between H. pylori infection and the serum lipid profile revealed that H. pylori infection is positively associated with LDL-C, TC, and TG (standardized mean difference [SMD] (95%CI) = 0.11 (0.09-0.12), 0.09 (0.07-0.10) and 0.06 (0.05-0.08), respectively) and negatively associated with HDL-C (SMD = -0.13 (-0.14 to -0.12)).ConclusionBoth our multivariate analyses and meta-analysis showed that H. pylori infection significantly affects the serum lipid profile, which might lead to various dyslipidemia-induced severe diseases like coronary thrombosis or cerebral infarction.
Databáze: OpenAIRE
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