Short-term oral toxicity of 2,4,6-trinitrotoluene in mice, rats, and dogs
| Autor: | Gordon W. Newell, Charles A. Tyson, Ronald J. Spanggord, James V. Dilley, Jack C. Dacre, Daniel P. Sasmore |
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| Rok vydání: | 1982 |
| Předmět: |
Male
medicine.medical_specialty Anemia Hemosiderosis Hematocrit Biology Toxicology Waste Disposal Fluid Transaminase Lethal Dose 50 chemistry.chemical_compound Mice Dogs Species Specificity Internal medicine medicine Animals Water Pollutants medicine.diagnostic_test Dose-Response Relationship Drug Cholesterol Body Weight Capsule Rats Inbred Strains medicine.disease Pollution Rats Endocrinology Blood chemistry Female Hemoglobin Corn oil Water Pollutants Chemical Trinitrotoluene |
| Zdroj: | Journal of toxicology and environmental health. 9(4) |
| ISSN: | 0098-4108 |
| Popis: | The short-term oral toxicity of 2,4,6-trinitrotoluene (alpha-TNT) was determined in dogs, rats, and mice. Single-dose oral LD50s for alpha-TNT in corn oil were 1320 and 794 mg/kg in male and female rats, respectively, and 660 mg/kg in both male and female mice. For multiple-dose studies, dogs were dosed daily for up to 13 wk with alpha-TNT at 0, 0.2, 2.0, or 20 mg/kg by capsule; rats received 0, 0.002, 0.01, 0.05, or 0.25% and mice received 0, 0.001, 0.005, 0.025, or 0.125% alpha-TNT in their diets over the same period. All species receiving the highest doses exhibited anemia, with reduced erythrocytes, hemoglobin, and hematocrit. Alterations were observed in organ weights, including enlarged spleens (accompanied by hemosiderosis) and livers, and depressed body weight and/or body weight gain (temporary in dogs and mice). Alterations in clinical chemistry values included elevated cholesterol and depressed serum glutamicpyruvic transaminase activity in dogs and rats; no effect on serum glutamic-oxaloacetic transaminase activity was observed. Some effects, such as SGPT depression in rats, appeared after 13 wk, suggesting a cumulative toxicity. Reduced testes size was observed in rats at the highest dose regardless of length of exposure. Most of the toxic effects were reversible, but testicular atrophy was not in rats allowed a 4-wk recovery period after treatment. Signs of anemia were present at intermediate dose levels. "No observable effects" levels for alpha-TNT were: dogs, 0.20; rats, 1.42; and mice, 7.76 mg/kg . d. |
| Databáze: | OpenAIRE |
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