Stealth Iron Oxide Nanoparticles for Organotropic Drug Targeting
| Autor: | Ike Olivotto, Juri Ugolotti, Massimiliano Magro, Anna Paola Fifi, Fabio Vianello, Emanuela Bonaiuto, Sonia Pasquaroli, Radek Zboril, Giuseppe Radaelli, Giulia Chemello, Claudia Aparicio, Davide Baratella, Jessica de Almeida Roger, Giorgio Cozza, Daniela Bertotto, Leonardo Mancini, Giovanni Miotto, Giorgio Zoppellaro |
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| Rok vydání: | 2019 |
| Předmět: |
Polymers and Plastics
Metal Nanoparticles Bioengineering 02 engineering and technology Plasma protein binding 010402 general chemistry Ferric Compounds 01 natural sciences Mass Spectrometry Biomaterials chemistry.chemical_compound Drug Delivery Systems In vivo Materials Chemistry Animals Distribution (pharmacology) Chromatography High Pressure Liquid Fishes 021001 nanoscience & nanotechnology 0104 chemical sciences Cell biology chemistry Targeted drug delivery Blood-Brain Barrier Lipoprotein transport Drug delivery Nanomedicine 0210 nano-technology Iron oxide nanoparticles Protein Binding |
| Zdroj: | Biomacromolecules. 20:1375-1384 |
| ISSN: | 1526-4602 1525-7797 |
| Popis: | The ability of peculiar iron oxide nanoparticles (IONPs) to evade the immune system was investigated in vivo. The nanomaterial was provided directly into the farming water of zebrafish ( Danio rerio) and the distribution of IONPs and the delivery of oxytetracycline (OTC) was studied evidencing the successful overcoming of the intestinal barrier and the specific and prolonged (28 days) organotropic delivery of OTC to the fish ovary. Noteworthy, no sign of adverse effects was observed. In fish blood, IONPs were able to specifically bind apolipoprotein A1 (Apo A1) and molecular modeling showed the structural analogy between the IONP@Apo A1 nanoconjugate and high-density lipoprotein (HDL). Thus, the preservation of the biological identity of the protein suggests a plausible explanation of the observed overcoming of the intestinal barrier, of the great biocompatibity of the nanomaterial, and of the prolonged drug delivery (benefiting of the lipoprotein transport route). The present study promises novel and unexpected stealth materials in nanomedicine. |
| Databáze: | OpenAIRE |
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