Prostatic tissue levels of ofloxacin
| Autor: | J. Knes, J. Aagaard, Paul O. Madsen |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Ofloxacin medicine.medical_specialty Dose Premedication Urology medicine.medical_treatment Administration Oral Pharmacokinetics Prostate Humans Medicine heterocyclic compounds Aged Antibacterial agent Transurethral resection of the prostate Prostatectomy business.industry biochemical phenomena metabolism and nutrition bacterial infections and mycoses Surgery medicine.anatomical_structure business medicine.drug |
| Zdroj: | Urology. 38:380-382 |
| ISSN: | 0090-4295 |
| DOI: | 10.1016/0090-4295(91)80159-5 |
| Popis: | The prostatic tissue levels of ofloxacin were determined in 20 patients undergoing transurethral resection of the prostate. Ofloxacin was administered in two separate dosages of 300 mg PO from twenty-two to two hours preoperatively. The ofloxacin plasma concentrations ranged from 3.73 to 1.85 micrograms/mL at the time of surgery, and the tissue concentrations ranged from 4.55 to 1.94 micrograms/mL. The ofloxacin tissue/plasma ratios ranged from 0.9 to 1.2. These findings indicate that ofloxacin may be useful in prophylaxis prior to transurethral prostatic surgery and also in the treatment of bacterial prostatitis. |
| Databáze: | OpenAIRE |
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