Abnormal measles-mumps-rubella antibodies and CNS autoimmunity in children with autism
| Autor: | Courtney Nelson, Vijendra K. Singh, Sheren X. Lin, Elizabeth Newell |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adolescent
Endocrinology Diabetes and Metabolism Clinical Biochemistry Central nervous system Hemagglutinins Viral Autoimmunity Enzyme-Linked Immunosorbent Assay Antibodies Viral medicine.disease_cause Measles virus Neurodevelopmental disorder Risk Factors mental disorders medicine Animals Humans Pharmacology (medical) Autistic Disorder Child Antigens Viral Molecular Biology Autoantibodies biology business.industry Biochemistry (medical) Autoantibody Antibodies Monoclonal Myelin Basic Protein Cell Biology General Medicine biology.organism_classification medicine.disease Virology Myelin basic protein medicine.anatomical_structure Child Preschool Immunology biology.protein Autism Antibody business Measles-Mumps-Rubella Vaccine |
| Zdroj: | Journal of Biomedical Science. 9:359-364 |
| ISSN: | 1423-0127 1021-7770 |
| DOI: | 10.1007/bf02256592 |
| Popis: | Autoimmunity to the central nervous system (CNS), especially to myelin basic protein (MBP), may play a causal role in autism, a neurodevelopmental disorder. Because many autistic children harbor elevated levels of measles antibodies, we conducted a serological study of measles-mumps-rubella (MMR) and MBP autoantibodies. Using serum samples of 125 autistic children and 92 control children, antibodies were assayed by ELISA or immunoblotting methods. ELISA analysis showed a significant increase in the level of MMR antibodies in autistic children. Immunoblotting analysis revealed the presence of an unusual MMR antibody in 75 of 125 (60%) autistic sera but not in control sera. This antibody specifically detected a protein of 73-75 kD of MMR. This protein band, as analyzed with monoclonal antibodies, was immunopositive for measles hemagglutinin (HA) protein but not for measles nucleoprotein and rubella or mumps viral proteins. Thus the MMR antibody in autistic sera detected measles HA protein, which is unique to the measles subunit of the vaccine. Furthermore, over 90% of MMR antibody-positive autistic sera were also positive for MBP autoantibodies, suggesting a strong association between MMR and CNS autoimmunity in autism. Stemming from this evidence, we suggest that an inappropriate antibody response to MMR, specifically the measles component thereof, might be related to pathogenesis of autism. |
| Databáze: | OpenAIRE |
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