An increasing prevalence of recombinant GII norovirus in pediatric patients with diarrhea during 2010–2013 in China
| Autor: | Hong-Yu Wang, Wei Liu, Wu-Chun Cao, Xiao-Ai Zhang, Fen Qu, Qing-Bin Lu, Dou-Dou Huang, Hong-Mei Xu, Jin Zhao |
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| Rok vydání: | 2015 |
| Předmět: |
Diarrhea
Male Microbiology (medical) China medicine.medical_specialty Adolescent Genes Viral Genotype viruses Biology medicine.disease_cause Microbiology law.invention fluids and secretions Public health surveillance law Prevalence Genetics medicine Humans Public Health Surveillance Child Molecular Biology Phylogeny Ecology Evolution Behavior and Systematics Caliciviridae Infections Recombination Genetic Public health Norovirus Infant Newborn Infant virus diseases Virology Infectious Diseases Child Preschool Recombinant DNA Female Seasons medicine.symptom |
| Zdroj: | Infection, Genetics and Evolution. 31:48-52 |
| ISSN: | 1567-1348 |
| Popis: | Noroviruses are the primary cause of acute nonbacterial gastroenteritis in humans and are responsible for nearly half of gastroenteritis cases globally. The norovirus strain variants have been circulating in underdeveloped regions in western China, where pediatric diarrhea acts as the major public health concern. The study aims to identify the epidemic genotypes of norovirus and explore their genetic characteristics in Chongqing, China. By performing a hospital-based surveillance from 2010 to 2013, we identified a significant shift of the predominant Norovirus strains in recent 4years in the studied area. The GII.4_Sydney_2012 and GII.12/GII.3 strains replaced GII.4_2006b and GII.4_NewOrleans_2009 to become the predominant genotypes, with the proportion of ORF1/ORF2 recombinants rising steadily from 2010 to 2013. A new GII.12/GII.3 variant that was seldom detected became a predominant genotype during the study course. Several distinct genotypes of norovirus, including GII.16/GII.2, GII.21/GII.3, GII.15 and GII.6, were also detected. The rising circulation of recombination in Chongqing illustrated the significance of recombination, especially in the ORF1/ORF2 overlap region, in the evolution and epidemic of norovirus. The epidemic of GII.12/GII.3 in Chongqing also serves as a reminder that prolonged surveillance is warranted for better prevention and control of norovirus infection. |
| Databáze: | OpenAIRE |
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