Inactivation of medial prefrontal cortex or acute stress impairs odor span in rats
| Autor: | Quentin Greba, Don A. Davies, John G. Howland, Joel J. Molder |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Cognitive Neuroscience Conditioning Classical Prefrontal Cortex Short-term memory behavioral disciplines and activities Statistics Nonparametric Article Olfaction Disorders 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Reward Reaction Time medicine Animals Rats Long-Evans 0501 psychology and cognitive sciences GABA-A Receptor Agonists 050102 behavioral science & comparative psychology Acute stress Prefrontal cortex Muscimol Working memory fungi 05 social sciences medicine.disease Rats Memory Short-Term Neuropsychology and Physiological Psychology chemistry Odor Schizophrenia Odorants Psychology Neuroscience Stress Psychological psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | Learning & memory (Cold Spring Harbor, N.Y.) |
| ISSN: | 1549-5485 |
| DOI: | 10.1101/lm.032243.113 |
| Popis: | The capacity of working memory is limited and is altered in brain disorders including schizophrenia. In rodent working memory tasks, capacity is typically not measured (at least not explicitly). One task that does measure working memory capacity is the odor span task (OST) developed by Dudchenko and colleagues. In separate experiments, the effects of medial prefrontal cortex (mPFC) inactivation or acute stress on the OST were assessed in rats. Inactivation of the mPFC profoundly impaired odor span without affecting olfactory sensitivity. Acute stress also significantly reduced odor span. These findings support a potential role of the OST in developing novel therapeutics for disorders characterized by impaired working memory capacity. |
| Databáze: | OpenAIRE |
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