New flavone and other compounds from Tephrosia egregia: assessing the cytotoxic effect on human tumor cell lines
| Autor: | Dilailson C. Costa-Junior, Raquel Carvalho Montenegro, Maria da Conceição F. de Oliveira, Raimundo Braz-Filho, Paulo Riceli Vasconcelos Ribeiro, Italo Gomes Pereira, Gilvandete M. P. Santiago, Mary Anne Sousa Lima, Maria Elisabete Amaral de Moraes, Mirna Marques Bezerra, Jefferson Q. Lima, Angela M. C. Arriaga, Aline Carla de Medeiros, Antônia Torres Ávila Pimenta, Danilo D. Rocha, Maria V. S. Teixeira, Francisca Renata Lopes da Silva |
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| Jazyk: | angličtina |
| Předmět: |
Flavonoids
biology 010405 organic chemistry Tephrosia Stereochemistry lcsh:RS1-441 Fabaceae biology.organism_classification 01 natural sciences Cinnamic acid 0104 chemical sciences lcsh:Pharmacy and materia medica 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Glucoside Cell culture Cytotoxic T cell Cytotoxicity activity General Pharmacology Toxicology and Pharmaceutics Cytotoxicity Flavonoides Two-dimensional nuclear magnetic resonance spectroscopy Flavone |
| Zdroj: | Revista Brasileira de Farmacognosia, Vol 28, Iss 3, Pp 333-338 Revista Brasileira de Farmacognosia v.28 n.3 2018 Revista Brasileira de Farmacognosia Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA Repositório Institucional da Universidade Federal do Ceará (UFC) Universidade Federal do Ceará (UFC) instacron:UFC Revista Brasileira de Farmacognosia, Volume: 28, Issue: 3, Pages: 333-338, Published: JUN 2018 Revista Brasileira de Farmacognosia, Vol 28, Iss 3, Pp 333-338 (2018) |
| Popis: | The organic extracts from stems, roots and leaves of Tephrosia egregia Sandwith, Fabaceae, provided a new flavone, 5-hydroxy-8-(1″,2″-epoxy-3″-hydroxy-3″-methylbutyl)-7-methoxyflavone (1), in addition to eleven known compounds: pongaflavone (2), praecansone B (3), 12a-hydroxyrotenone (4), praecansone A, 2′,6′-dimethoxy-4′,5′-(2″,2″-dimethyl)-pyranochalcone, pongachalcone, maackiain, β-sistosterol and its glucoside, p-cumaric acid and cinnamic acid. The structures of all compounds were established on the basis of spectroscopic methods, mainly 1D and 2D NMR and HRESIMS, involving comparison with literature data. Cytotoxicity of compounds 1–4 was evaluated against AGP-01 (cancerous ascitic fluid), HCT-116 (colon adenocarcinoma), HL-60 (leukemia), PC-3 (prostate carcinoma), SF-295 (glioblastoma) and SKMEL 28 (melanoma) cell lines. Keywords: Tephrosia, Flavone, Flavonoids, Cytotoxicity activity |
| Databáze: | OpenAIRE |
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