CCR5Δ32 Polymorphism Associated with a Slower Rate Disease Progression in a Cohort of RR-MS Sicilian Patients
| Autor: | Aldo Amato, Antonina Sidoti, Concetta Crisafulli, Alessia Ruggeri, Rosalia D'Angelo, Carmela Rinaldi |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Pathology Article Subject Population Disease lcsh:RC346-429 Multiple sclerosis Internal medicine Genetic predisposition medicine Allele education lcsh:Neurology. Diseases of the nervous system sicilian education.field_of_study Expanded Disability Status Scale CCR5Δ32 Polymorphism business.industry medicine.disease Cohort Etiology Neurology (clinical) business Research Article |
| Zdroj: | Multiple Sclerosis International Multiple Sclerosis International, Vol 2011 (2011) |
| ISSN: | 2090-2662 2090-2654 |
| Popis: | Multiple sclerosis (MS) disease is carried through inflammatory and degenerative stages. Based on clinical feaures, it can be subdivided into three groups: relapsing-remitting MS, secondary progressive MS, and primary progressive MS. Multiple sclerosis has a multifactorial etiology with an interplay of genetic predisposition, environmental factors, and autoimmune inflammatory mechanism in which play a key role CC-chemokines and its receptors. In this paper, we studied the frequency of CCR5 gene Δ32 allele in a cohort of Sicilian RR-MS patients comparing with general Sicilian population. Also, we evaluate the association between this commonly polymorphism and disability development and age of disease onset in the same cohort. Our results show that presence of CCR5Δ32 is significantly associated with expanded disability status scale score (EDSS) but not with age of disease onset. |
| Databáze: | OpenAIRE |
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