The protective effects of the methylenetetrahydrofolate reductase rs1801131 variant among Saudi smokers
| Autor: | Nouf S. Al-Numair, Mikhlid Almutairi, Bader Almutairi, Narasimha Reddy Parine, Abdulwahed F. Alrefaei, Abdelhabib Semlali, Mahmoud Rouabhia |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
0301 basic medicine Oncology medicine.medical_specialty QH301-705.5 Population Disease 01 natural sciences Saudi 03 medical and health sciences Polymorphism (computer science) Internal medicine Genotype medicine Allele Polymorphism Biology (General) education Allele frequency Rs1801131 education.field_of_study biology business.industry Methylenetetrahydrofolate reductase Smoking Cancer medicine.disease 030104 developmental biology biology.protein Original Article General Agricultural and Biological Sciences business 010606 plant biology & botany |
| Zdroj: | Saudi Journal of Biological Sciences, Vol 28, Iss 7, Pp 3972-3980 (2021) Saudi Journal of Biological Sciences |
| Popis: | Methylenetetrahydrofolate reductase (MTHFR) polymorphism plays a fundamental role in susceptibility to various diseases, including cancers and autoimmune diseases. In the current study, we aimed to compare genotype and allele frequency variations of rs1801131, one of the most common variants found in the MTHFR gene, among Saudi smokers and non-smokers. We hypothesized that genetic variations of this gene are responsible for many diseases, particularly those caused by cigarette smoking (CS) such as pulmonary diseases, oral cancer and lung cancer. We performed a case-control study on a sample of 235 healthy smokers and 239 healthy non-smokers in Saudi Arabia. The rs1801131 SNP genotypes were determined using a genotyping assay and multiple in silico algorithmic software programs were used to identify the effects and structural functions of the rs1801131 (Glu429Ala) mutation. Using chi-squared tests, we found that, among smokers, TG and GG genotype carriers had 0.209-fold (OR = 0.209, P |
| Databáze: | OpenAIRE |
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