Squamous Epithelial Proliferative Lesions Associated with Rhesus Epstein-Barr Virus in Simian Immunodeficiency Virus-Infected Rhesus Monkeys
| Autor: | Chris Zurcher, E. D. Roberts, Dorothy Kuebler, Louis N. Martin, Jonathan L. Heeney, Bep Blauw, Gary B. Baskin |
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| Rok vydání: | 1995 |
| Předmět: |
Hairy leukoplakia
Herpesvirus 4 Human Pathology medicine.medical_specialty viruses Simian Acquired Immunodeficiency Syndrome Opportunistic Infections Biology Simian medicine.disease_cause Epithelium Virus medicine Animals Immunology and Allergy Gammaherpesvirinae Skin Oral hairy leukoplakia Mucous Membrane Herpesviridae Infections Simian immunodeficiency virus biology.organism_classification medicine.disease Macaca mulatta Virology Epstein–Barr virus Tumor Virus Infections Infectious Diseases Simian AIDS |
| Zdroj: | Journal of Infectious Diseases. 172:535-539 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Proliferative lesions were found on the squamous epithelium of the tongue, esophagus, or penis or haired skin of the lip, hand, or thorax of 8 simian immunodeficiency virus-infected rhesus monkeys that died of simian AIDS. The lesions were focal and consisted of hyperkeratosis, parakeratosis, and acanthosis in the skin, with additional ballooning degeneration in the tongue, esophagus, and penis. The epithelial surfaces were frequently colonized by Candida species or gram-positive cocci. Intranuclear inclusion bodies were seen in cells in the middle and superficial layers. Herpesvirus virions were found in inclusion-bearing cells by transmission electron microscopy. An Epstein-Barr-like virus was identified in inclusion-bearing cells by immunohistochemistry and in situ hybridization. No virus was detectable in basal layers of the epithelium. These lesions resemble oral hairy leukoplakia in AIDS patients and may thus provide a useful primate model to study permissive epithelial infection by Epstein-Barr-like viruses. |
| Databáze: | OpenAIRE |
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