Effects of Dietary Sodium and Genetic Background on Angiotensinogen and Renin in Mouse
| Autor: | Jennifer Thomas, Tracy Herrmann, Jean-Marc Lalouel, Gray Petty, Daniel A. Terreros, Tong Cheng, Kenneth Ward, Tomoaki Ishigami, Elaine Hillas, Andreas Rohrwasser, Pierre Lantelme, Sha Xiao, Barbu Gociman |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Sodium Angiotensinogen chemistry.chemical_element Nephron Plasma renin activity Mice Species Specificity Internal medicine Renin Renin–angiotensin system Internal Medicine medicine Animals RNA Messenger Aldosterone Renal sodium reabsorption urogenital system Sodium Dietary Immunohistochemistry Connecting tubule Mice Inbred C57BL Kidney Tubules medicine.anatomical_structure Endocrinology Gene Expression Regulation chemistry Creatinine Homeostasis Low sodium |
| Zdroj: | Hypertension. 39:1007-1014 |
| ISSN: | 1524-4563 0194-911X |
| Popis: | Elements of a renin-angiotensin system expressed along the entire nephron, including angiotensinogen secreted by proximal tubule and renin expressed in connecting tubule, may participate in the regulation of sodium reabsorption at multiple sites of the nephron. The response of this tubular renin-angiotensin system to stepwise changes in dietary sodium was investigated in 2 mouse strains, the sodium-sensitive inbred C57BL/6 and the sodium-resistant CD1 outbred. Plasma angiotensinogen was not affected by sodium regimen, whereas plasma renin increased 2-fold under low sodium. In both strains, the variation in urinary parameters did not parallel the changes observed in plasma. Angiotensinogen and renin excretion were significantly higher under high sodium than under low sodium. Water deprivation, by contrast, induced significant activation in the tubular expression of angiotensinogen and renin. C57BL/6 exhibited significantly higher urinary excretion of angiotensinogen than did CD1 animals under both conditions of sodium intake. The extent to which these urinary parameters reflect systemic or tubular responses to challenges of sodium homeostasis may depend on the relative contribution of sodium restriction and volume depletion. |
| Databáze: | OpenAIRE |
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