Recent advances in applying nanotechnologies for cancer immunotherapy
| Autor: | Reza Mahjub, Griffin Pauli, Zhu Qin, Meysam Soleimani, Sukhdeep Jatana, Soheil Madadi, Suen Ern Lee, Shyh-Dar Li |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Pharmaceutical Science 02 engineering and technology Immunoadjuvant 03 medical and health sciences Immune system Cancer immunotherapy Antigen Immunity Neoplasms Nucleic Acids medicine Animals Humans Nanotechnology Antigens Tumor microenvironment Vaccines business.industry Antibodies Monoclonal Immunotherapy 021001 nanoscience & nanotechnology 3. Good health 030104 developmental biology Drug delivery Cancer research 0210 nano-technology business Peptides |
| Zdroj: | Journal of controlled release : official journal of the Controlled Release Society. 288 |
| ISSN: | 1873-4995 |
| Popis: | Cancer immunotherapy aimed at boosting cancer-specific immunoresponses to eradicate tumor cells has evolved as a new treatment modality. Nanoparticles incorporating antigens and immunomodulatory agents can activate immune cells and modulate the tumor microenvironment to enhance anti-tumor immunity. The nanotechnology approach has been demonstrated to be superior to standard formulations in in-vivo settings. In this article, we focus on recent advances made within the last 5 years in nanoparticle-based cancer immunotherapy, including peptide- and nucleic acid-based nanovaccines, nanomedicines containing an immunoadjuvant to activate anti-tumor immunity, nanoparticle delivery of immune checkpoint inhibitors and the combination of the above approaches. Encouraging results and new emerging nanotechnologies in drug delivery promise the continuous growth of this field and ultimately clinical translation of enhanced immunotherapy of cancer. |
| Databáze: | OpenAIRE |
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