Genetic findings in miscarriages and their relation to the number of previous miscarriages
| Autor: | M Amrani, N Hafezi, Christine Skala, P Thomas, S Schweiger, R Gomez, Annette Hasenburg, C Lieb, M K Dewenter |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Abortion Habitual Chromosomal disorders Adolescent Early Pregnancy Loss 610 Medizin Early pregnancy loss Chromosome Disorders Abortion Logistic regression Miscarriage Maternal-Fetal Medicine 03 medical and health sciences 0302 clinical medicine Pregnancy 610 Medical sciences medicine Humans 030212 general & internal medicine Retrospective Studies Chromosome Aberrations 030219 obstetrics & reproductive medicine Obstetrics business.industry Obstetrics and Gynecology Karyotype General Medicine Middle Aged medicine.disease Abortion Spontaneous Karyotyping Gestation Female Parity (mathematics) business Number of previous miscarriages Maternal Age |
| Zdroj: | Archives of Gynecology and Obstetrics |
| ISSN: | 1432-0711 0932-0067 |
| Popis: | Purpose Early pregnancy loss leads to a devastating situation for many couples. Genetic disorders found in the pregnancy tissue are a frequent cause of miscarriages. It is unclear whether maternal age or previous miscarriages are associated with a higher chromosomal anomaly rate. This study aimed to determine the cytogenetical distribution of chromosomal disorders in couples after one or more previous miscarriages as well as the influence of maternal age. Methods 406 fetal tissue samples obtained after spontaneous abortion between 2010 and 2014 were successfully karyotyped. This included 132 couples with at least two losses and 274 couples with sporadic miscarriage. Normal and abnormal karyotype rate was determined for age, parity, gravidity, gestational week and number of previous miscarriages by logistic regression analysis. Results 145 (35.71%) fetal tissue samples had a normal karyotype, and 261 (64.8%) did not. After adjusting for age, older patients have a statistically significantly higher probability of genetic disorders in the pregnancy tissue (p p = 0.014, OR 0.67, 95% CI 0.48–0.914). Nevertheless, the risk of embryonic chromosomal disorders in patients aged 35 and above increased from 75.5% in sporadic miscarriages to 82.4% after more than one pregnancy losses (p = 0.59, OR 1.14, 95% CI − 0.72 to 1.92). Conclusion Chromosomal disorders found after one or more previous miscarriages are related to patients’ age. Couples suffering two or more miscarriages should be further researched, especially in younger patients. |
| Databáze: | OpenAIRE |
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