The role of Fibroblast growth factor binding protein 1 in skin carcinogenesis and inflammation
| Autor: | Dirk H. Busch, Jan Rozman, Robert Brommage, Helmut Fuchs, Raffi Bekeredjian, Lillian Garrett, Sabine M. Hölter, Anton Wellstein, Julia Calzada-Wack, Holger Maier, T. Klopstock, Ralph Steinkamp, Yong Gu Lee, Johannes Beckers, Marion Horsch, Patrick James Beck, Martin Hrabé de Angelis, Khalid Garman, Carsten B. Schmidt-Weber, Annemarie Zimprich, Claudia Stoeger, Marcel O. Schmidt, L. Becker, Eckhard Wolf, Thure Adler, Jochen Graw, Chong Zuo, Ildiko Racz, Irina Treise, Andreas Zimmer, Alexandra Vernaleken, Juan Antonio Aguilar-Pimentel, Wolfgang Hans, Wolfgang Wurst, Mingjun Tan, Stefanie Leuchtenberger, Christoph Lengger, Martin Klingenspor, Patricia da Silva-Buttkus, Elena Tassi, Anna T. Riegel, Valerie Gailus-Durner, Birgit Rathkolb, Manuela A. Östereicher, Markus Ollert, Kristin Moreth, Frauke Neff, Oana V. Amarie |
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| Jazyk: | němčina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Carrier Proteins/genetics Pathology Neoplasms Experimental/chemically induced Skin Neoplasms Angiogenesis Carcinogenesis Fibroblast growth factor Biochemistry Mice Wound Healing/physiology Bone Marrow Inflammation/genetics Fibroblast growth factor binding Bone Marrow Transplantation Skin Mice Knockout integumentary system Intracellular Signaling Peptides and Proteins Fgf Inflammation Wound Healing Up-Regulation medicine.anatomical_structure Knockout mouse Intercellular Signaling Peptides and Proteins Tetradecanoylphorbol Acetate Female Carcinogenesis/pathology Tetradecanoylphorbol Acetate/toxicity medicine.medical_specialty Dermatology Biology Article 03 medical and health sciences medicine Animals Humans Fibroblast Molecular Biology Matrigel Bone Marrow/metabolism Papilloma Cell Biology Squamous cell skin cancer Neoplasms Experimental Skin Neoplasms/chemically induced Water Loss Insensible Mice Inbred C57BL 030104 developmental biology Skin/drug effects Cancer research Carcinogens Papilloma/chemically induced Wound healing Carrier Proteins Carcinogens/toxicity |
| Zdroj: | J. Invest. Dermatol. 138, 179-188 (2018) Schmidt, M O, Garman, K A, Lee, Y G, Zuo, C, Beck, P J, Tan, M, Aguilar-Pimentel, J A, Ollert, M, Schmidt-Weber, C, Fuchs, H, Gailus-Durner, V, Hrabe de Angelis, M, Tassi, E, Riegel, A T, Wellstein, A & German Mouse Clinic Consortium 2018, ' The Role of Fibroblast Growth Factor Binding Protein 1 in Skin Carcinogenesis and Inflammation ', Journal of Investigative Dermatology, vol. 138, no. 1, pp. 179-188 . https://doi.org/10.1016/j.jid.2017.07.847 |
| DOI: | 10.1016/j.jid.2017.07.847 |
| Popis: | Fibroblast growth factor-binding protein 1 (FGFBP1) is a secreted chaperone that mobilizes paracrine-acting FGFs, stored in the extracellular matrix, and presents them to their cognate receptors. FGFBP1 enhances FGF signaling including angiogenesis during cancer progression and is upregulated in various cancers. Here we evaluated the contribution of endogenous FGFBP1 to a wide range of organ functions as well as to skin pathologies using Fgfbp1-knockout mice. Relative to wild-type littermates, knockout mice showed no gross pathologies. Still, in knockout mice a significant thickening of the epidermis associated with a decreased transepidermal water loss and increased proinflammatory gene expression in the skin was detected. Also, skin carcinogen challenge by 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoyl-phorbol-13-acetate resulted in delayed and reduced papillomatosis in knockout mice. This was paralleled by delayed healing of skin wounds and reduced angiogenic sprouting in subcutaneous matrigel plugs. Heterozygous green fluorescent protein (GFP)–knock-in mice revealed rapid induction of gene expression during papilloma induction and during wound healing. Examination of wild-type skin grafted onto Fgfbp1 GFP–knock-in reporter hosts and bone marrow transplants from the GFP-reporter model into wild-type hosts revealed that circulating Fgfbp1-expressing cells migrate into healing wounds. We conclude that tissue-resident and circulating Fgfbp1-expressing cells modulate skin carcinogenesis and inflammation. |
| Databáze: | OpenAIRE |
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