Have lichenized fungi delivered promising anticancer small molecules?
| Autor: | Robert Kiss, Willem A. L. van Otterlo, Pier Luigi Nimis, Marco Masi, Alessio Cimmino, Laura De Gara, Florence Lefranc, Antonio Evidente |
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| Přispěvatelé: | Cimmino, A., Nimis, P. L., Masi, M., de Gara, L., van Otterlo, W. A. L., Kiss, R., Evidente, A., Lefranc, F., Nimis, Pierluigi, Cimmino, Alessio, Masi, Marco, De Gara, Laura, AL van Otterlo, Willem, Kiss, Robert, Evidente, Antonio, Lefranc, Florence |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
compound Chemistry Lichen Computational biology Plant Science lichen 01 natural sciences Small molecule Anticancer activity Endolichen fungi 0104 chemical sciences stomatognathic diseases 010404 medicinal & biomolecular chemistry lichens compounds cancer Bioactive metabolite Human cancer 010606 plant biology & botany Biotechnology |
| Popis: | This review, covering the literature from 1844 to present (end 2017), probes questions concerning small molecule metabolites derived from lichens (lichenized fungi) and their impact in terms of providing compounds with significant promise in oncology. The review gives an overview of lichenized fungi and summarizes the classes of compounds obtained as metabolites from these organisms. A definition of what characteristics an actual “promising” anticancer compound should possess is also delineated. The review reports a brief overview on human cancer and then goes into depth in listing compounds with so-called “anticancer properties” that have been isolated from lichenized fungi, according to their small molecule structural classes. Five “most promising” compounds are discussed in-depth, also considering the possibility of obtaining sufficient amounts for further investigations. |
| Databáze: | OpenAIRE |
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