HLA, atopy, and cyclophosphamide in steroid-responsive childhood nephrotic syndrome
| Autor: | John F. Soothill, T. Martin Barratt, Richard Kay, Richard S. Trompeter, Malcolm W. Turner |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Hypersensitivity
Immediate Pediatrics medicine.medical_specialty Nephrotic Syndrome Time Factors Cyclophosphamide Eczema Human leukocyte antigen Childhood nephrotic syndrome Atopy HLA Antigens Recurrence medicine Humans Child Skin Tests Gynecology business.industry Incidence (epidemiology) Rhinitis Allergic Seasonal Immunoglobulin E Steroid responsive medicine.disease Asthma Nephrology High incidence business Nephrotic syndrome medicine.drug |
| Zdroj: | Kidney International. 17:113-117 |
| ISSN: | 0085-2538 |
| DOI: | 10.1038/ki.1980.13 |
| Popis: | HLA, atopy, and cyclophosphamide in steroid-responsive childhood nephrotic syndrome. In a study designed to confirm our preliminary report of associations between HLA-B12, atopy, and relapse following cyclophosphamide treatment in steroid-responsive nephrotic syndrome (SRNS), we again found a higher incidence of HLA-B12 in SRNS children (44%) than we did in controls (24%). The association of HLA-B12 with short time-to-relapse after cyclophosphamide treatment of SRNS was also confirmed, but that with atopy in SRNS children was not, though we observed a similarly high incidence of atopy in them as before. HLA, atopie, et cyclophosphamide au cours du syndrome nephrotique cortico sensible de l'enfant. Au cours d'une etude destinee a confirmer notre observation preliminaire d'associations entre HLA-B12, atopie et recidive apres traitement par le cyclophosphamide du syndrome nephrotique cortico sensible (SRNS) nous avons a nouveau constate une frequence plus elevee de HLA-B12 chez les enfants atteints de SRNS (44%) que chez les controles (24%). L'association de HLA-B12 avec des recidives a court terme apres traitement par le cyclophosphamide de SNRS a aussi ete comfirmee, mais celle avec l'atopie chez les enfants SNRS ne l'a pas ete, bien que nous ayons observe la meme incidence elevee d'atopie chez ces sujets qu'auparavant. |
| Databáze: | OpenAIRE |
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