Exogenous hydrogen sulfide gas does not induce hypothermia in normoxic mice
| Autor: | Michal Heger, Thomas M. van Gulik, Marcel Cornelis Dirkes, Rick Bezemer, Sebastiaan D. Hemelrijk, Marit H. N. van Velzen |
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| Přispěvatelé: | Anesthesiology, Graduate School, Other departments, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Surgery |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Suspended animation genetic structures Hydrogen sulfide metabolism Hydrogen sulfide chemistry.chemical_element lcsh:Medicine Hypothermia Oxygen Article Body Temperature 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Oxygen Consumption stomatognathic system Hypothermia Induced Internal medicine Thermographic imaging medicine Animals Hydrogen Sulfide Hypoxia lcsh:Science Multidisciplinary Chemistry Oxygen metabolism lcsh:R technology industry and agriculture Hypoxia (environmental) equipment and supplies humanities Mice Inbred C57BL 030104 developmental biology Endocrinology Female lcsh:Q medicine.symptom 030217 neurology & neurosurgery psychological phenomena and processes |
| Zdroj: | Scientific Reports, 8:3855. Nature Publishing Group Scientific reports, 8(1). Nature Publishing Group Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Hydrogen sulfide (H2S, 80 ppm) gas in an atmosphere of 17.5% oxygen reportedly induces suspended animation in mice; a state analogous to hibernation that entails hypothermia and hypometabolism. However, exogenous H2S in combination with 17.5% oxygen is able to induce hypoxia, which in itself is a trigger of hypometabolism/hypothermia. Using non-invasive thermographic imaging, we demonstrated that mice exposed to hypoxia (5% oxygen) reduce their body temperature to ambient temperature. In contrast, animals exposed to 80 ppm H2S under normoxic conditions did not exhibit a reduction in body temperature compared to normoxic controls. In conclusion, mice induce hypothermia in response to hypoxia but not H2S gas, which contradicts the reported findings and putative contentions. |
| Databáze: | OpenAIRE |
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