Repeated courses of antenatal corticosteroids have adverse effects on aspects of brain development in naturally delivered baboon infants
Autor: | Amy Shields, Merran A. Thomson, Sandra Rees, Jacqueline J. Coalson, Vicki T. Winter |
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Rok vydání: | 2012 |
Předmět: |
Brain development
viruses Bioinformatics Injections Intramuscular Article Fetal Development Adrenal Cortex Hormones Pregnancy biology.animal Glial Fibrillary Acidic Protein Animals Adverse effect Dose-Response Relationship Drug biology Brain Myelin Basic Protein Oligodendroglia Animals Newborn Astrocytes Models Animal embryonic structures Pediatrics Perinatology and Child Health Immunology Female Papio Baboon |
Zdroj: | Pediatric Research. 71:661-667 |
ISSN: | 1530-0447 0031-3998 |
Popis: | Repeated courses of antenatal steroids in women at risk of preterm delivery have beneficial effects on lung maturation, but concern exists about the effects on brain development. We aimed to determine whether repeated courses of corticosteroids increased the risk of neuropathology as compared with single courses or no treatment.Single-course animals received a 6-mg dose of steroids at 123 and 124 d of gestation (dg; term, 185 dg; n = 6). Repeated-course animals received additional doses at 137 and 138 dg (n = 7). Controls received no steroids (n = 5). Baboons delivered naturally at term and necropsy was performed. Brains were assessed histologically for parameters of development and neuropathology.Body weights did not differ between the groups (P0.05); neither did brain/body weight ratio. Density of glial fibrillary acidic protein (GFAP)-immunoreactive (IR) astrocytes in white matter (WM) was increased in the single- (P0.05) and repeated-course (P0.01) groups as compared with controls. Density of myelin basic protein (MBP)-IR oligodendrocytes was reduced in the repeated-course animals as compared with both the control and single-course groups (P0.05); oligodendrocyte transcription factor 2 (Olig2)-IR showed no difference between groups.Repeated courses of antenatal corticosteroids have effects on myelination in the developing nonhuman primate brain, which should be taken into account when determining a dosing regimen. |
Databáze: | OpenAIRE |
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