Synthesis and Antimicrobial Evaluation of a New Series of N-1,3-Benzothiazol-2-ylbenzamides

Autor: Marilena Muraglia, Alessia Carocci, Antonio Rosato, Filomena Corbo, Alessia Catalano, Carlo Franchini, Ivana Defrenza, Domenico Armenise, Nicolino De Laurentis
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Journal of Chemistry, Vol 2013 (2013)
ISSN: 2090-9071
2090-9063
Popis: Enterococcus faecalisis a Gram-positive commensal inhabitant of the intestinal tract of humans, animals, and insects. However, it is also an opportunistic pathogen and has emerged as a leading cause of hospital-acquired extraintestinal infections. Fluoroquinolones have been frequently used to treatE. faecalisinfections, and the emergence of fluoroquinolone-resistantE. faecalisstrains has recently been reported in several countries. Thus, the identifications of new antibiotics specifically directed toE. faecalismay be envisaged. In this paper, a new series ofN-1,3-benzothiazol-2-ylbenzamides have been designed, synthesized, and evaluated for theirin vitroantimicrobial activities. Among the tested compounds,3iwas active againstE. faecalis.
Databáze: OpenAIRE
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