Oxidative stress in proliferative lesions of parathyroid gland
| Autor: | Grzegorz Buła, Joanna Polczyk, Ewa Romuk, Mariusz Deska, Jacek Gawrychowski, Oliwia Segiet |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty endocrine system diseases Glutathione reductase medicine.disease_cause Antioxidants Superoxide dismutase Parathyroid Glands 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Blood serum Postoperative Complications Internal medicine medicine Humans Glutathione transferase activity Aged Cell Proliferation chemistry.chemical_classification Aged 80 and over biology business.industry Glutathione peroxidase Hyperparathyroidism General Medicine Glutathione Middle Aged Malondialdehyde Oxidative Stress 030104 developmental biology Endocrinology chemistry 030220 oncology & carcinogenesis biology.protein Surgery Female Lipid Peroxidation business Oxidative stress |
| Zdroj: | Polski przeglad chirurgiczny. 91(1) |
| ISSN: | 2299-2847 |
| Popis: | Background: Primary hyperparathyroidism (PHPT) is one of the most common endocrine disorders and defined as excessive secretion of parathormone. PHPT is a risk factor of several cardiovascular diseases, which could be caused by alterations in oxidant-antioxidant balance. Materials and methods: Blood serum collected from 52 consecutive patients with PHPT treated surgically constituted our study material, whereas 36 healthy volunteers were our control group. Oxidative stress was evaluated in both patients and control subjects by assessment of malondialdehyde (MDA) and lipid hydroperoxides (LHP). Antioxidants were evaluated by the measurement of superoxide dismutase (SOD), ceruloplasmin (CER), catalase (CAT), sulfhydryl (SH) groups, glutathione (GSH), glutathione peroxidase (GSH-Px), glutathione transferase activity (GST) and glutathione reductase (GR). Moreover total antioxidant capacity (TAC) and total oxidative status (TOS) were measured and oxidative stress index (OSI) was calculated. Results: OSI was increased in patients with PHPT when compared to normal controls, whereas TAC was lower in PHPT. The levels of CER, MnSOD, GR, SH groups and MDA were significantly decreased in PHPT. The levels of serum LHP, catalase and SOD were significantly higher in patients with PHPT than in healthy patients. The erythrocyte CAT activity and GST were significantly increased in patients after parathyroidectomy. The erythrocyte GR and GPx were up-regulated postoperatively, whereas SOD activity decreased. Conclusions: In PHPT there are several alterations in the balance between the production of reactive oxygen species and antioxidant defense system. |
| Databáze: | OpenAIRE |
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