Intracellular degradation of newly synthesized casein in perfused rat mammary gland

Autor:	MA Kerr, Colin J. Wilde, DT Calvert
Rok vydání:	1991
Předmět:	In situ Caseins Chloroquine Rats Inbred Strains Intracellular Membranes General Medicine Rat Mammary Gland Biology Prolactin Rats Perfusion Adenosine Triphosphate Mammary Glands Animal Biochemistry Casein Animals Degradation (geology) Female Secretion Proline Intracellular
Zdroj:	Experimental Physiology. 76:533-537
ISSN:	0958-0670
DOI:	10.1113/expphysiol.1991.sp003519
Popis:	Degradation of newly synthesized casein in rat mammary gland perfused in situ was measured by a pulse-chase method using [3H]proline. Casein degradation during secretion was observed in the absence of prolactin, but not with prolactin present. Partial inhibition by chloroquine showed that hormone-dependent degradation occurred intracellularly by a lysosomal mechanism. The study indicates that this post-translational mechanism is a physiological regulator of net casein secretion.
Databáze:	OpenAIRE
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