Behaviour of telocytes during physiopathological activation
| Autor: | Lucio Díaz-Flores, Ricardo Gutiérrez, Miriam González Goméz, Francisco J. Sáez, Juan F. Madrid |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Cell type Stromal cell CD34 Antigens CD34 Cell Communication Biology Extracellular matrix 03 medical and health sciences symbols.namesake 0302 clinical medicine Neoplasms medicine Animals Humans Telocytes Cell Shape Tissue homeostasis Cell Biology Hyperplasia medicine.disease Interstitial cell of Cajal 030104 developmental biology 030220 oncology & carcinogenesis Immunology symbols Stromal Cells Myofibroblast Developmental Biology |
| Zdroj: | Seminars in celldevelopmental biology. 55 |
| ISSN: | 1096-3634 |
| Popis: | We consider CD34+ stromal cells/telocytes (CD34+ SC/TCs) in normal and pathological conditions. These cells are involved in organisation and control of the extracellular matrix, structural support, creation of microenvironments, intercellular communication, neurotransmission, immunomodulation and immunosurveillance, inhibition of apoptosis, and control, regulation and source of other cell types. CD34+ SC/TCs are widely reported in the origin of interstitial cells of Cajal and in regeneration in the heart, skeletal muscle, skin, respiratory tree, liver, urinary system and the eye. In addition, we contribute CD34+ SC/TC hyperplasia associated with several processes, including neurogenous hyperplasia (neuroma of the appendix), hyperplasia of Leydig cells in undescended testes (Cryptorchidism), peripheral areas of inflammatory/repair processes (pericicatricial tissue and transitional zones between diseased segments in Crohn's disease and normal bowel), benign tumours (neurofibromas, Antoni-B zones of neurilemmomas, granular cell tumours, and melanocytic nevi) and in some lesions with myxoid, oedematous and degenerative changes (Reinke's oedema, myxomatous mitral valve degeneration, thyroid-associated ophthalmopathy and basophilic degenerative changes of the collagen in the dermis). We pay particular attention to the role of CD34+ SC/TCs during repair through granulation tissue, including morphologic changes, loss of CD34 expression and gain of αSMA expression with myofibroblast transformation, and interactions with pericytes, endothelial and inflammatory cells. Finally, we consider CD34 or αSMA expression in stromal cells of malignant epithelial tumours, and the role of CD34+ SC/TCs in the origin of carcinoma-associated fibroblasts (CAFs) and myofibroblasts. In conclusion, CD34+ SC/TCs play an important role in the maintenance and modulation of tissue homeostasis and in morphogenesis/renewal/repair. |
| Databáze: | OpenAIRE |
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