Tissue Factor Expression Does Not Predict Mortality in Breast Cancer Patients
| Autor: | Silke Hausladen, Thomas F. Lüscher, Jens P. Hellermann, Felix C. Tanner, Alexander Akhmedov, Konstantin J. Dedes, Simon F. Stämpfli, Zsuzsanna Varga, Alexander Breitenstein, Glen Kristiansen |
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| Přispěvatelé: | University of Zurich, Breitenstein, Alexander |
| Rok vydání: | 2017 |
| Předmět: |
Oncology
Adult Cancer Research medicine.medical_specialty Time Factors 610 Medicine & health Breast Neoplasms Kaplan-Meier Estimate Metastasis Thromboplastin 03 medical and health sciences Tissue factor 0302 clinical medicine Breast cancer Predictive Value of Tests 10049 Institute of Pathology and Molecular Pathology Internal medicine medicine Biomarkers Tumor Humans 1306 Cancer Research 030212 general & internal medicine Thrombus Survival analysis Aged Aged 80 and over business.industry Carcinoma Ductal Breast General Medicine Ductal carcinoma Middle Aged medicine.disease Thrombosis Immunohistochemistry 10174 Clinic for Gynecology Tumor Burden Carcinoma Lobular Receptors Estrogen Hormone receptor 030220 oncology & carcinogenesis Lymphatic Metastasis 10209 Clinic for Cardiology 2730 Oncology Female Neoplasm Grading business |
| Zdroj: | Anticancer research. 37(6) |
| ISSN: | 1791-7530 |
| Popis: | BACKGROUND Tissue factor (TF), the trigger of coagulation, not only initiates thrombus formation, but also elicits tumor growth and invasion in breast cancer. However, the characterization of TF expression in breast cancer tissue and its prognostic value remain unclear. MATERIALS AND METHODS Three hundred and three primary breast cancer specimens from the local tumor tissue database were immunostained for TF expression and evaluated semiquantitatively. Tumor characteristics (size, grade, nodal status, and ER expression) as well as patient's survival were assessed. RESULTS Expression of TF was detected in 99% of specimens with higher expression in invasive lobular than ductal carcinoma (p=0.008). TF expression correlated with ER expression (p |
| Databáze: | OpenAIRE |
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