O-GlcNAcase inhibitors as potential therapeutics for the treatment of Alzheimer’s disease and related tauopathies: analysis of the patent literature

Autor:	José Manuel Bartolomé-Nebreda, Adriana Ingrid Velter, Peter Jacobus Johannes Antonius Buijnsters, Andrés A. Trabanco
Rok vydání:	2021
Předmět:	Patent literature Tau protein tau Proteins O-GlcNAcase Disease 01 natural sciences Patents as Topic Mice 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Drug Discovery Animals Humans Phosphorylation Pharmacology chemistry.chemical_classification biology General Medicine beta-N-Acetylhexosaminidases 0104 chemical sciences 010404 medicinal & biomolecular chemistry Enzyme Tauopathies chemistry Biochemistry 030220 oncology & carcinogenesis biology.protein Protein Processing Post-Translational
Zdroj:	Expert Opinion on Therapeutic Patents. 31:1117-1154
ISSN:	1744-7674 1354-3776
DOI:	10.1080/13543776.2021.1947242
Popis:	Introduction: O-GlcNAcylation is a highly abundant post-translational modification of multiple proteins, including the microtubule-binding protein tau, governed by just two enzymes’ concerted actio...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee8ef238f0aa8391ae62a82b47711df https://doi.org/10.1080/13543776.2021.1947242 Zobrazit plný text záznamu