CD4(+) CD56(+) Lineage-Negative Malignancies Are Rare Tumors of Plasmacytoid Dendritic Cells
| Autor: | Carla S. Wilson, David S. Viswanatha, Richard S. Larson, Kaaren K. Reichard, John Hozier, M. Kathryn Foucar, Eric J. Burks |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Pathology medicine.medical_specialty Myeloid CD33 Plasmacytoid dendritic cell Biology Malignancy Stem cell marker Pathology and Forensic Medicine Natural killer cell Biomarkers Tumor medicine Humans Cell Lineage In Situ Hybridization Aged Aged 80 and over Reverse Transcriptase Polymerase Chain Reaction hemic and immune systems Dendritic Cells Gene rearrangement Middle Aged Prognosis medicine.disease Immunohistochemistry CD56 Antigen medicine.anatomical_structure Hematologic Neoplasms CD4 Antigens Female Surgery Bone marrow Anatomy |
| Zdroj: | American Journal of Surgical Pathology. 29:1274-1283 |
| ISSN: | 0147-5185 |
| DOI: | 10.1097/01.pas.0000172194.32918.5c |
| Popis: | CD4(+) CD56(+) lineage-negative malignancies are difficult to diagnose and classify. Recent studies have suggested that these malignancies may derive from plasmacytoid dendritic cells (pDC). In this report, we examine 10 cases of CD4+, CD56+ lineage-negative malignancies that presented in various tissue sites. The goal was to identify the morphologic, immunophenotypic, and genotypic findings to devise a diagnostic approach to tissue biopsies of these lesions and to confirm the proposed cell of origin. The mean age was 66 years (range, 45-80 years) with a male predominance (8 males/2 females). Frequent sites of disease included skin (60%) and peripheral blood/bone marrow (70%). Tumor cells were positive for CD45, CD43, CD4, and CD56 (9 of 10). The pDC markers, CD123 (9 of 10) and CD45RA (10 of 10), were detected by immunoperoxidase staining. Also noted was CD2 positivity (1 case), weak CD7 positivity (4 of 8 cases), weak CD33 (4 of 9 cases), TdT (2 cases), and CD68 (2 cases). All cases were otherwise negative for EBV (EBER), B-cell, T-cell, myeloid, and NK cell markers. T-cell receptor-gamma gene rearrangement was negative in all cases. Complex structural chromosomal abnormalities were seen in 3 of 5 cases, a subset of which may be recurrent in pDC malignancy. Overall prognosis was poor despite multiagent chemotherapy and/or radiation. Our study confirms that CD4+/CD56+ lineage-negative tumors are derived from pDC and have characteristic clinical, histopathologic, and immunophenotypic features. Furthermore, these rare neoplasms can be readily diagnosed using recently developed immunoperoxidase techniques. |
| Databáze: | OpenAIRE |
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