Renal inflammation and elevated blood pressure in a mouse model of reduced β-ENaC
| Autor: | Monette Gousset, David E. Stec, John Michael Barnard, Rumbidayzi Chiposi, Beau Murphey, Heather A. Drummond, Ahmed Abu-Zaid, Samira C. Grifoni |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Epithelial sodium channel medicine.medical_specialty Hypertension Renal Physiology Blood Pressure Motor Activity Biology Muscle Smooth Vascular Renal Circulation Constriction Mice Heart Rate Internal medicine medicine Animals Homeostasis Autoregulation Epithelial Sodium Channels Nephritis Renal circulation urogenital system Articles Blood flow respiratory system medicine.disease Endocrinology Blood pressure medicine.anatomical_structure Female |
| Zdroj: | American Journal of Physiology-Renal Physiology. 301:F443-F449 |
| ISSN: | 1522-1466 1931-857X |
| DOI: | 10.1152/ajprenal.00694.2010 |
| Popis: | Previous studies suggest β-epithelial Na+channel protein (β-ENaC) may mediate myogenic constriction, a mechanism of blood flow autoregulation. A recent study demonstrated that mice with reduced levels of β-ENaC (β-ENaC m/m) have delayed correction of whole kidney blood flow responses, suggesting defective myogenic autoregulatory capacity. Reduced renal autoregulatory capacity is linked to renal inflammation, injury, and hypertension. However, it is unknown whether β-ENaC m/m mice have any complications associated with reductions in autoregulatory capacity such as renal inflammation, injury, or hypertension. To determine whether the previously observed altered autoregulatory control was associated with indicators of renal injury, we evaluated β-ENaC m/m mice for signs of renal inflammation and tissue remodeling using marker expression. We found that inflammatory and remodeling markers, such as IL-1β, IL-6, TNF-α, collagen III and transforming growth factor-β, were significantly upregulated in β-ENaC m/m mice. To determine whether renal changes were associated with changes in long-term control of blood pressure, we used radiotelemetry and found that 5-day mean arterial blood pressure (MAP) was significantly elevated in β-ENaC m/m (120 ± 3 vs. 105 ± 2 mmHg, P = 0.016). Our findings suggest loss of β-ENaC is associated with early signs of renal injury and increased MAP. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|