Fast odour dynamics are encoded in the olfactory system and guide behaviour
| Autor: | Debanjan Dasgupta, Tom P. A. Warner, Julia J. Harris, Andreas T. Schaefer, Izumi Fukunaga, Tobias Ackels, Andrew Erskine, Sina Tootoonian, Alina Cristina Marin |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Olfactory system Male Scene segmentation Patch-Clamp Techniques Time Factors Sensory processing medicine.medical_treatment Models Neurological Spatial Behavior Biology Olfactory Receptor Neurons Article 03 medical and health sciences Mice 0302 clinical medicine parasitic diseases medicine Animals Air Movements Multidisciplinary Olfactory receptor Behavior Animal fungi food and beverages Temporal correlation Olfactory Bulb Olfactory bulb Mice Inbred C57BL Smell Electrophysiology 030104 developmental biology medicine.anatomical_structure Odorants behavior and behavior mechanisms Conditioning Operant Neuroscience 030217 neurology & neurosurgery psychological phenomena and processes |
| Zdroj: | Nature |
| ISSN: | 1476-4687 |
| Popis: | Odours are transported in turbulent plumes, which result in rapid concentration fluctuations1,2 that contain rich information about the olfactory scenery, such as the composition and location of an odour source2–4. However, it is unclear whether the mammalian olfactory system can use the underlying temporal structure to extract information about the environment. Here we show that ten-millisecond odour pulse patterns produce distinct responses in olfactory receptor neurons. In operant conditioning experiments, mice discriminated temporal correlations of rapidly fluctuating odours at frequencies of up to 40 Hz. In imaging and electrophysiological recordings, such correlation information could be readily extracted from the activity of mitral and tufted cells—the output neurons of the olfactory bulb. Furthermore, temporal correlation of odour concentrations5 reliably predicted whether odorants emerged from the same or different sources in naturalistic environments with complex airflow. Experiments in which mice were trained on such tasks and probed using synthetic correlated stimuli at different frequencies suggest that mice can use the temporal structure of odours to extract information about space. Thus, the mammalian olfactory system has access to unexpectedly fast temporal features in odour stimuli. This endows animals with the capacity to overcome key behavioural challenges such as odour source separation5, figure–ground segregation6 and odour localization7 by extracting information about space from temporal odour dynamics. Fast temporal dynamics of the olfactory environment can be perceived by mice and used to perform scene segmentation. |
| Databáze: | OpenAIRE |
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