Vitamin D status correlates with the markers of cystic fibrosis-related pulmonary disease
| Autor: | Javeed Iqbal Bhat, Syed Wajid Ali, Mudasir Nazir, Qazi Iqbal Ahmad, Wasim A. Wani, Bashir Ahmad Charoo, Ehsan-ul-haq Malik |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Vitamin
Lung Diseases Male medicine.medical_specialty Adolescent Cystic Fibrosis Gastroenterology Cystic fibrosis vitamin D deficiency Pulmonary function testing 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine 030225 pediatrics Internal medicine Forced Expiratory Volume medicine Vitamin D and neurology Humans Colonization Vitamin D Child Lung Retrospective Studies Respiratory tract infections business.industry Incidence (epidemiology) lcsh:RJ1-570 lcsh:Pediatrics medicine.disease Vitamin D Deficiency 030228 respiratory system chemistry Child Preschool Pediatrics Perinatology and Child Health Female business Biomarkers |
| Zdroj: | Pediatrics and Neonatology, Vol 60, Iss 2, Pp 210-215 (2019) |
| ISSN: | 1875-9572 |
| Popis: | Background: The prevalence of Vitamin D deficiency remains high in cystic fibrosis despite daily supplementation. Vitamin D as an immunomodulator has been related to lower respiratory tract infections in children. The present study was undertaken to examine the association between vitamin D status and markers of cystic fibrosis-related pulmonary disease including exacerbations, bacterial colonization and pulmonary function. Methods: The study includes review of records of 51 cystic fibrosis patients. Baseline patient variables and serum vitamin D levels were recorded. Based on vitamin D levels study patients were divided into three groups: vitamin-D sufficient (≥20 ng/mL), vitamin-D insufficient (12 to 20 ng/mL), and vitamin D-deficient (≤12 ng/ml). Results: The proportion of children with deficient, insufficient and sufficient vitamin D levels were 47.1%, 15.7%, and 37.2%, respectively. Female sex, bacterial colonization and a greater number of exacerbations were associated with highest odds of developing vitamin D deficiency in patients with CF with 1.77 (0.22–4.61) (p = 0.002), 2.9(0.57−14.82) (p = 0.011), and 5.12 (1.28−20.50) (p = 0.021) respectively. The comparison of vitamin-D levels taken during exacerbations, colonization and during routine follow-up were significant [16.04 (7.42−27.91), 24.3 (15.5−32.4) and 48.54 (18.37−78.7) ng/ml, p |
| Databáze: | OpenAIRE |
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