Drug delivery to the posterior segment of the eye for pharmacologic therapy
Autor: | Jasmine R Elison, Tashfin S. Huq, Christian Clement, Partha S. Bhattacharjee, Lori Vidal Denham, Shalin S Shah, James M. Hill |
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Jazyk: | angličtina |
Rok vydání: | 2010 |
Předmět: |
Drug
medicine.medical_specialty business.industry media_common.quotation_subject Biomedical Engineering Diabetic retinopathy Macular degeneration medicine.disease Article Surgery Posterior segment of eyeball Transplantation Ophthalmology Retinitis pigmentosa Drug delivery medicine Cytomegalovirus retinitis business Optometry media_common |
Popis: | Treatment of diseases of the posterior segment of the eye, such as age-related macular degeneration, cytomegalovirus retinitis, diabetic retinopathy, posterior uveitis and retinitis pigmentosa, requires novel drug delivery systems that can overcome the many barriers for efficacious delivery of therapeutic drug concentrations. This challenge has prompted the development of biodegradable and nonbiodegradable sustained-release systems for injection or transplantation into the vitreous as well as drug-loaded nanoparticles, microspheres and liposomes. These drug delivery systems utilize topical, systemic, subconjunctival, intravitreal, transscleral and iontophoretic routes of administration. The focus of research has been the development of methods that will increase the efficacy of spatiotemporal drug application, resulting in more successful therapy for patients with posterior segment diseases. This article summarizes recent advances in the research and development of drug delivery methods of the posterior chamber of the eye, with an emphasis on the use of implantable devices as well as micro- and nanoparticles. |
Databáze: | OpenAIRE |
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