Treatment of Respiratory Klebsiella pneumoniae Infection in Mice with Aerosols of Kanamycin
| Autor: | G. G. Long, J. S. Walker, R. F. Berendt |
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| Rok vydání: | 1975 |
| Předmět: |
Time Factors
Klebsiella pneumoniae complex mixtures Injections Intramuscular Microbiology Aerosol therapy Mice Kanamycin medicine Animals Pharmacology (medical) Particle Size Respiratory system Aerosolization Aerosols Pharmacology Mice Inbred ICR biology Pneumonia Klebsiella infections respiratory system medicine.disease biology.organism_classification Pharmacology and Therapeutics Virology respiratory tract diseases Klebsiella Infections Infectious Diseases Female Pneumonia (non-human) Bacteria medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 8:585-590 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.8.5.585 |
| Popis: | Aerosols of kanamycin resulted in greater survival of mice challenged with respiratory Klebsiella pneumoniae than the same dosage given intramuscularly. Determinations of viable bacteria in the blood and lungs revealed that aerosolized kanamycin was most effective when infection was confined to the lungs. After the organisms had spread to other areas, however, aerosol therapy was still more effective than intramuscular therapy, but only one-half the infected mice survived. |
| Databáze: | OpenAIRE |
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