A retrospective observational study of low-level viraemia and its immunological and virological significance: which outcome to expect
| Autor: | Joana Silva, Teresa Baptista Alberto, Kamal Mansinho, Helena Farinha, Perpétua Gomes, João Rijo, Karen Pereira, J Cabanas |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Pediatrics
medicine.medical_specialty Low-level viraemia business.industry Public Health Environmental and Occupational Health Retrospective cohort study medicine.disease Persistence (computer science) Antiretroviral therapy Regimen Infectious Diseases Poster Sessions – Abstract P136 Acquired immunodeficiency syndrome (AIDS) Cohort medicine HIV-1 In patient business Prospective cohort study Viral load |
| Zdroj: | Journal of the International AIDS Society Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação instacron:RCAAP |
| Popis: | Introduction : Low-level viraemia (LLV) is observed in some patients with HIV-1 infection on stable antiretroviral therapy (ART). The significance of these findings remains controversial as it conflicts with traditional optimal clinic outcome. This study aims to evaluate the effect of LLV on the establishment of virological failure (VF) and immune deterioration. Methods : Retrospective observational study of a cohort of HIV-1 infected patients of an Infectious Diseases Clinic, who presented an HIV-1 viral load of 20 to 200 cp/mL, during the year 2012. Patients who were not on ART or non-adherent in the previous 6 months were excluded. Compliance was quantified by clinical and pharmaceutical records. Adherence was defined as ≥95% compliance rate. Demographic, clinical, immunological and therapeutic data were collected from clinical records. LLV was defined as a range of 20–200 cp/mL and stratified as transient (T-LLV): only one measurement, persistent (P-LLV): 2 consecutive measurements with an interval ≥3 months and recurrent (R-LLV): ≥1 T-LLV during an 18-month follow-up. Statistical analysis was performed with Microsoft Office ® – Excel 2012. Kolmogorov – Smirnov test, t -test and chi-square test were performed for a significant p value |
| Databáze: | OpenAIRE |
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