Particle pollution in Rio de Janeiro, Brazil: Increase and decrease of pro-inflammatory cytokines IL-6 and IL-8 in human lung cells
| Autor: | Mario G. Ortiz-Martínez, Vinicius L. Mateus, Rosa I. Rodríguez-Cotto, Evasomary Rivera-Ramírez, Adriana Gioda, Braulio Jiménez-Vélez, Beatriz S. Amaral |
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| Rok vydání: | 2014 |
| Předmět: |
Pollution
Health Toxicology and Mutagenesis medicine.medical_treatment media_common.quotation_subject Toxicology complex mixtures Article Microbiology Proinflammatory cytokine Environmental protection Air Pollution medicine Humans Interleukin 8 Interleukin 6 media_common Inhalation exposure Air Pollutants Inhalation Exposure biology Interleukin-6 Chemistry Interleukin-8 Epithelial Cells General Medicine In vitro Cytokine biology.protein Particulate Matter Cytokine secretion Brazil Environmental Monitoring |
| Zdroj: | Environmental Pollution. 194:112-120 |
| ISSN: | 0269-7491 |
| Popis: | Particle pollution from urban and industrialized regions in Rio de Janeiro (RJ), Brazil was analyzed for toxic and pro-inflammatory (cytokines: IL-6, IL-8, IL-10) responses in human bronchial epithelial cells. Trace elements contribution was studied. Airborne particulate matter was collected at: three industrial sites Ind-1 (PM10) and Ind-2a and 2b (PM2.5); Centro urban area (PM10) and two rural sites (PM2.5, PM10). PM10 acetone extracts were toxic and did not elicit cytokine release; aqueous extracts were less toxic and stimulated the release of IL-6 and IL-8. PM2.5 aqueous extracts from Ind-2 decreased the release of IL-6 and IL-8. Zinc concentration was higher at the industrial and rural reference sites (Ref-1-2) although metals were not associated to cytokines changes. These results demonstrate that PM from RJ can either increase or decrease cytokine secretion in vitro while being site specific and time dependent. |
| Databáze: | OpenAIRE |
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