Zero-stress state of intra- and extraparenchymal airways from human, pig, rabbit, and sheep lung
| Autor: | Peter D. Paré, Roger D. Kamm, Barry Wiggs, Karen McKay |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Swine Physiology Biology Physiology (medical) Parenchyma Pressure medicine Animals Humans Respiratory system Lung Bronchus Sheep Lagomorpha Rabbit (nuclear engineering) Anatomy Middle Aged respiratory system biology.organism_classification respiratory tract diseases medicine.anatomical_structure Female Rabbits Airway Respiratory tract |
| Zdroj: | Journal of Applied Physiology. 92:1261-1266 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/japplphysiol.00131.2001 |
| Popis: | Alterations in airway wall anatomic properties and the consequential effects on airway narrowing have been assessed by use of computational models. In these models, it is generally assumed that at zero transmural pressure the airway wall exists in a zero-stress state. Many studies have shown that this is often not the case, as evidenced by a nonzero opening angle. In this study, we measured the opening angle of airway rings at zero transmural pressure to test this assumption. The airway tree was dissected from human, pig, sheep, and rabbit lungs. Airways were excised from the tree, and the opening angle was measured. There were obvious species and regional differences in opening angle. Rabbit airways from both extraparenchymal and intraparenchymal sites exhibited marked opening angles (7–82°). Extraparenchymal airways from sheep had large opening angles (up to 50°), but ovine intraparenchymal airways had small opening angles. Measurable opening angles were rarely observed in human and porcine airways of any size. The assumption of a stable zero-stress state at zero transmural pressure is therefore valid for human and porcine, but not rabbit and sheep, airways. |
| Databáze: | OpenAIRE |
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