Sex differences in association between cognitive impairment and clinical correlates in Chinese patients with first-episode drug-naïve schizophrenia
| Autor: | Chuan Yi Kang, Tie Feng Guan, Hunter C. Hinman, Ran Wei, Xiaohong Wang, Li Ying Yang, Yue Zheng, Yun Xia Bai, Xiang Yang Zhang, Na Zhao |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
RC435-571 MCCB Verbal learning First-episode drug-naïve patients 03 medical and health sciences Cognition 0302 clinical medicine Hamd Medicine Psychiatry First episode Positive and Negative Syndrome Scale business.industry Sex difference medicine.disease Mental illness 030227 psychiatry Psychiatry and Mental health Drug-naïve Schizophrenia Primary Research business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Annals of General Psychiatry Annals of General Psychiatry, Vol 20, Iss 1, Pp 1-9 (2021) |
| Popis: | Background Schizophrenia is a complex mental illness with significant sex differences. Cognitive impairment is common in patients with schizophrenia, even in remission. This study was designed to examine the sex differences in the relationship between cognitive impairment and clinical correlations with first-episode drug-naïve (FEDN) schizophrenia. Methods 93 FEDN patients (male/female = 45/48) and 160 controls (male/female = 74/86) were enrolled to compare the sex differences in cognitive functions measure by the MATRICS Consensus Cognitive Battery (MCCB). Positive and Negative Syndrome Scale (PANSS) and Hamilton Depression Scale (HAMD) were used to evaluated patients' clinical symptoms. We compared cognitive impairment with sociodemographic characteristics and measures of different genders, as well as group-by-sex interactions. Results Our results showed that the MCCB total and index score in FEDN were lower than in the control group, except for category fluency and social cognition. Male patients had significantly lower symbol coding, digital sequence, and verbal learning scores than female patients, and the controls showed a similar sex difference. Interestingly, we also found six indexes and MCCB total score that showed diagnosis-by-sex interactions, belonging to the speed of processing, attention, working memory, and verbal learning. The MCCB total score showed correlations with PANSS total score and education for both genders. In female patients, education showed significant positive correlations with MCCB total and all ten index scores. Multiple linear regression analysis confirmed that negative symptoms and general psychopathology of PANSS, HAMD total score, and education were independent contributors to MCCB total score. In male patients, only education was an independent contributor to MCCB total score. Conclusions These findings revealed significant sex differences in cognitive impairments and clinical symptoms in FEDN. These results should be considered, which will be worthy of a follow-up study of schizophrenia in the future. |
| Databáze: | OpenAIRE |
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