Intragastric acidity as a predictor of the success of Helicobacter pylori eradication: a study in peptic ulcer patients with omeprazole and amoxicillin
| Autor: | Manfred Stolte, A. L. Blum, Sollböhmer M, Joachim Labenz, I Jorias, J Bertrams, Gereon Börsch, F. Leverkus |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Gastroenterology Helicobacter Infections Gastric Acid Recurrence Internal medicine medicine Humans Prospective Studies Stomach Ulcer Omeprazole Aged Antibacterial agent Helicobacter pylori biology business.industry Stomach Anti-ulcer Agent Amoxicillin Middle Aged Anti-Ulcer Agents biology.organism_classification Anti-Bacterial Agents Treatment Outcome medicine.anatomical_structure Duodenal Ulcer Gastric acid Drug Therapy Combination Female Gastritis medicine.symptom business Research Article medicine.drug |
| Zdroj: | Gut. 37:39-43 |
| ISSN: | 0017-5749 |
| DOI: | 10.1136/gut.37.1.39 |
| Popis: | Omeprazole plus amoxicillin cures Helicobacter pylori infection. The hypothesis was tested that low acidity is a predictor of outcome. Fifty patients with relapsing or complicated, or both H pylori positive duodenal (n = 25) or gastric ulcer (n = 25) were randomly treated with either omeprazole 20 mg twice daily plus amoxicillin 1 g twice daily or with omeprazole 40 mg twice daily plus amoxicillin 1 g twice daily over two weeks. After one week of combined treatment, a 24 hour gastric pH measurement was performed in all patients. H pylori cure rate was 67%. Patients who later turned out to be cured had higher pH values during night time and after meals (p < 0.05). In an explorative analysis drug compliance, smoking, location of the ulcer (duodenum versus stomach), age, and grade of body gastritis were additional predictors of the outcome. Smoking (p = 0.006), compliance (p = 0.037), duodenal ulcer disease (p = 0.065), and young age (p = 0.021) were related to high acidity. In conclusion, the success of eradication treatment with omeprazole and amoxicillin in ulcer patients infected with H pylori depends on intragastric pH. Drug compliance, smoking habits, location of ulcer, age, and activity of body gastritis are other predictors and in part related to intragastric acidity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|