Experimental antithrombotic effects of sesame seed whole grains and extracts
| Autor: | Aki Naemura, Kanae Hyodo, Chifumi Kinugasa, Junichiro Yamamoto, Masumi Katsuta, Yoshiki Nakai |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Administration Oral Dioxoles Diet High-Fat Lignans Sesamum chemistry.chemical_compound Ingredient Mice Fibrinolytic Agents Phenols Sesamin Antithrombotic Sesamolin Medicine Animals Humans Infusions Intra-Arterial Benzodioxoles Sesamol Active ingredient biology Traditional medicine business.industry Plant Extracts Lasers Thrombosis Hematology General Medicine biology.organism_classification Mice Inbred C57BL Disease Models Animal chemistry business Edible Grain Fibrinolytic agent |
| Zdroj: | Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis. 22(6) |
| ISSN: | 1473-5733 |
| Popis: | Prevention of arterial thrombotic diseases has a high priority in developed countries. An inappropriate diet is known to enhance the risks for acute thrombotic events, and nutritional products experimentally shown to be antithrombotic, might contribute beneficial effects. The present study forms part of a series of investigations into the antithrombotic effect of various foods and vegetables. Roasted and crushed whole grains from six varieties of sesame seeds were added to the diet of mice. Antithrombotic activity was measured in the carotid artery in vivo, using a He-Ne laser-induced thrombosis technique after 12 weeks. Col/Chichibu/Maruteru-2/1995 and T016 varieties showed significant antithrombotic activity, whilst 00037803 was prothrombotic. The acute effects of purified ingredients, sesamin, sesamolin and sesamol, given orally or intra-arterially, were also examined after a single dose. The most effective ingredient was sesamol, followed by sesamolin and sesamin. Daily intake of specific antithrombotic sesame whole grains or purified active ingredients might help to prevent atherothrombotic diseases. |
| Databáze: | OpenAIRE |
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