Absorption, metabolism, and pharmacokinetic profile of xanthohumol in rats as determined via UPLC-MS/MS

Autor:	Huan‐Huan Bai, Tian‐Shuang Xia, Yi‐Ping Jiang, Wu‐Mu Xu, Ping‐Cui Xu, Na‐Ni Wang, Xiao‐Jun Gou, Hai‐Liang Xin
Rok vydání:	2021
Předmět:	Pharmacology Flavonoids Rats Sprague-Dawley Propiophenones Tandem Mass Spectrometry Pharmaceutical Science Administration Oral Animals Pharmacology (medical) General Medicine Chromatography High Pressure Liquid Chromatography Liquid Rats
Zdroj:	Biopharmaceuticsdrug dispositionREFERENCES. 43(1)
ISSN:	1099-081X
Popis:	Xanthohumol, a natural isoflavone from Humulus lupulus L., possesses biological activities. However, the biological fate of xanthohumol in vivo remains unclear. The aim of this study was to investigate the absorption and metabolism of xanthohumol in rats through UPLC-MS/MS. The plasma, urine and fecal samples were collected after oral administration of xanthohumol (25, 50, 100 mg/kg) in SD rats. The contents of xanthohumol and its metabolites were determined by UPLC-MS/MS. A total of 6 metabolites of xanthohumol were identified in rats, including methylated, glucuronidated, acid-catalyzed cyclization and oxidation, indicating xanthohumol underwent phase I and II metabolism. Besides, isoxanthohumol was the major metabolites of xanthohumol. Xanthohumol was rapidly absorbed, metabolized, and eliminated in rats. The pharmacokinetics results showed the T
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed6d49a39d1ce426a7ed3c0ead6ca67 https://pubmed.ncbi.nlm.nih.gov/34914109 Zobrazit plný text záznamu Plný text