Targeting antibodies to the cytoplasm
| Autor: | Manuela Schüngel, Thomas Schirrmann, André Frenzel, Andrea L. J. Marschall, Stefan Dübel |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Cytoplasm
Protein Folding Phage display Immunology Cell Molecular Sequence Data Review Endocytosis Antibodies law.invention law medicine Human proteome project Immunology and Allergy Animals Humans Amino Acid Sequence biology Recombinant Proteins Cell biology Protein Transport medicine.anatomical_structure biology.protein Recombinant DNA Antibody Intracellular |
| Zdroj: | mAbs. 3(1) |
| ISSN: | 1942-0870 |
| Popis: | A growing number of research consortia are now focused on generating antibodies and recombinant antibody fragments that target the human proteome. A particularly valuable application for these binding molecules would be their use inside a living cell, e.g., for imaging or functional intervention. Animal-derived antibodies must be brought into the cell through the membrane, whereas the availability of the antibody genes from phage display systems allows intracellular expression. Here, the various technologies to target intracellular proteins with antibodies are reviewed. |
| Databáze: | OpenAIRE |
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