Is the interaction between ticlopidine and cyclosporin dose related? Report of three cases

Autor:	Rabea Bayahia, Hakima Rhou, Tarik Sqalli Houssaini, Asmaâ Laboudi, Fatima Ezzaitouni, Naima Ouzeddoun, Loubna Benamar
Rok vydání:	2011
Předmět:	business.industry General Medicine Cyclosporin Dose Pharmacology medicine.disease Kidney transplant Thrombosis Nephrology Cyclosporin a Kidney transplantation cyclosporine ticlopidine medicine Transplant patient Ticlopidine business Letter to the Editor Kidney transplantation medicine.drug
Zdroj:	The Libyan Journal of Medicine Libyan Journal of Medicine; Vol 5 (2010) incl Supplements
ISSN:	1819-6357 1993-2820
Popis:	Ticlopidine is an effective anti-platelet agent used for prevention of thrombosis. It was reported that treatment with ticlopidine at the dose of 250 mg daily in kidney transplant patients caused significant reduction of cyclosporin A (CsA) blood levels. In heart transplant patients treated with higher doses of ticlopidine 500 mg daily, it was found to cause significant decrease of cyclosporin concentration but not in those treated with only 250 mg daily. It was thought that ticlopidine interacts with cyclosporin metabolism at cytochrome P450. (Published: 1 July 2010) Citation: Libyan J Med 2010, 5: 5334 - DOI: 10.3402/ljm.v5i0.5334
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed5b321bc3ac47f8a32d9fdf611e508 https://pubmed.ncbi.nlm.nih.gov/21483566 Zobrazit plný text záznamu