Synthesis of imidazo[1,2-c]thiazoles through Pd-catalyzed bicyclization of tert-butyl isonitrile with thioamides
| Autor: | Ying-Ming Pan, Hai-Tao Tang, Mengyue Xu, Xiu-Jin Meng, Feng Qin, Xiang-Jun Peng, Shaojie Zhu, Heng-Shan Wang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Tert butyl Bicyclic molecule 010405 organic chemistry Chemistry Biomolecule Organic Chemistry 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry In vitro 0104 chemical sciences Catalysis Molecule MTT assay Physical and Theoretical Chemistry Thioamide |
| Zdroj: | Organic & Biomolecular Chemistry. 17:8403-8407 |
| ISSN: | 1477-0539 1477-0520 |
| Popis: | Building new biological molecules is challenging. Herein, imidazo[1,2-c]thiazoles were synthesized as a new class of heterobicyclic analogs through Pd-catalyzed cascade bicyclization from isonitriles with thioamides. The bicyclic scaffolds were constructed by inserting three molecules of isonitrile into two molecules of thioamide and then cyclizing them in a one-pot procedure. In vitro antitumor studies of these new compounds were conducted by using the MTT assay, and compound 3c showed excellent inhibitory effects against HepG2 at 7.06 ± 0.68 μM. |
| Databáze: | OpenAIRE |
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