Potential Role for Flubendazole in Limiting Filariasis Transmission: Observations of Microfilarial Sensitivity
| Autor: | Erica Burkman, Samuel Wanji, Jonas A. Kengne-Ouafo, Timothy G. Geary, Andrew R. Moorhead, Maeghan O’Neill, Patrick Chouna Ndongmo, Michael T. Dzimianski, Charles D. Mackenzie, Jelil Abdel Njouendou |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
030231 tropical medicine Mebendazole Flubendazole Pharmacology Brugia malayi Albendazole Loa 03 medical and health sciences chemistry.chemical_compound Macrofilaricide Loiasis 0302 clinical medicine Ivermectin Parasitic Sensitivity Tests Virology parasitic diseases medicine Animals Humans Microfilariae biology business.industry Articles biology.organism_classification Onchocerca volvulus Filariasis Culicidae Filaricides 030104 developmental biology Infectious Diseases chemistry Parasitology Loa loa business medicine.drug |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 98:21-26 |
| ISSN: | 1476-1645 0002-9637 |
| Popis: | Flubendazole (FLBZ) is a potent and efficacious macrofilaricide after parenteral administration. Studies in animal models and one trial in patients infected with Onchocerca volvulus revealed that FLBZ elicits minimal effects on microfilariae (mf). Severe complications after ivermectin (IVM) treatment of patients with high Loa loa microfilaraemia are of great concern. We examined the potential of FLBZ to rapidly kill L. loa mf, the phenomenon proposed to underlie the complications. Mf of L. loa were exposed to FLBZ, its reduced metabolite, albendazole, or IVM in vitro. Viability of L. loa mf was unaffected by FLBZ (10 μM, 72 hours); similar results were obtained with mf of Brugia malayi. We also measured the effects of FLBZ on transmission of mf. Aedes aegypti were fed FLBZ-exposed B. malayi mf and dissected 24 hours or 14 days postfeeding to count mf that crossed the midgut and developed to infective L3. FLBZ impaired the ability of mf to cross the midgut, regardless of duration of exposure (≥ 2 hours). FLBZ also prevented the development of mf to L3s, irrespective of duration of exposure or concentration. FLBZ is not microfilaricidal under these conditions; however, it blocks transmission. These results support the possibility that FLBZ may be a useful macrofilaricide in loiasis regions and may limit transmission from treated individuals. |
| Databáze: | OpenAIRE |
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