ZAR1 is a novel epigenetically inactivated tumour suppressor in lung cancer
| Autor: | Thorsten Stiewe, Antje M. Richter, Reinhard Dammann, Janina Breuer, Steffen Kiehl, Nicole Köger |
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| Přispěvatelé: | Institute for Genetics |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Lung Neoplasms Cell lcsh:Medicine Epigenesis Genetic 0302 clinical medicine Carcinoma Non-Small-Cell Lung Promoter Regions Genetic Genetics (clinical) DNA methylation Cell Cycle Cell cycle Life sciences medicine.anatomical_structure 030220 oncology & carcinogenesis Epigenetics Small Cell Lung Carcinoma Lung cancer Tumour suppressor tumour suppressor lcsh:QH426-470 Down-Regulation Biology 03 medical and health sciences ddc:570 Cell Line Tumor ZAR1 (zygote arrest 1) Genetics Carcinoma medicine Humans Molecular Biology Cell Proliferation epigenetics Cell growth Research lcsh:R Egg Proteins Cancer medicine.disease Molecular biology respiratory tract diseases lung cancer lcsh:Genetics 030104 developmental biology A549 Cells CpG Islands Developmental Biology |
| Zdroj: | Clinical Epigenetics Clinical Epigenetics, Vol 9, Iss 1, Pp 1-12 (2017) Clinical Epigenetics 9:60 doi: 10.1186/s13148-017-0360-4 |
| ISSN: | 1868-7083 1868-7075 |
| DOI: | 10.1186/s13148-017-0360-4 |
| Popis: | Background Lung cancer is the leading cause of cancer-related deaths with 1.8 million new cases each year and poor 5-year prognosis. Promoter hypermethylation of tumour suppressors leads to their inactivation and thereby can promote cancer development and progression. Results In this study, we analysed ZAR1 (zygote arrest 1), which has been said to be a maternal-effect gene and its expression mostly limited to certain reproductive tissues. Our study shows that ZAR1 is expressed in normal lung but inactivated by promoter methylation in lung cancer. ZAR1 is hypermethylated in primary lung cancer samples (22% small cell lung carcinoma (SCLC) and 76% non-small cell lung carcinoma (NSCLC), p |
| Databáze: | OpenAIRE |
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