An Asian study on the prevalence of atypical respiratory pathogens in community-acquired pneumonia
| Autor: | Yuet Meng Cheong, Mangunnegoro Hadiarto, Marissa M. Alejandria, Teerachai Chantarojanasriri, Jang Wook Sohn, Mediadora Saniel, Fu Wang, Po-Ren Hsueh, Youning Liu, Ahmad M. Aziah, Subharee Suwanjutha, Lee Ping-Ing, Wing-Hong Seto, Cecilia C.L. Ngan, Alsagaff Hood, Seung Chul Park, Yun Fong Ngeow |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
DNA Bacterial Male Microbiology (medical) Mycoplasma pneumoniae Asia Adolescent Community-acquired pneumonia medicine.disease_cause Polymerase Chain Reaction Legionella pneumophila Agglutination Tests Pneumonia Bacterial Prevalence medicine Humans Child Fluorescent Antibody Technique Indirect biology Asia Eastern business.industry Respiratory disease Antibody titer General Medicine Chlamydophila pneumoniae Middle Aged biology.organism_classification medicine.disease Atypical respiratory pathogens respiratory tract diseases Community-Acquired Infections Pneumonia Infectious Diseases Child Preschool Immunology Female Bacterial antigen business |
| Zdroj: | International Journal of Infectious Diseases. 9:144-153 |
| ISSN: | 1201-9712 |
| DOI: | 10.1016/j.ijid.2004.06.006 |
| Popis: | Summary Background: In many parts of Asia, the inaccessibility and high cost of diagnostic tests have hampered the study of community-acquired pneumonia (CAP) caused by atypical respiratory pathogens. Objective: This surveillance study examined the frequency of infection with Mycoplasma pneumoniae , Chlamydophila pneumoniae , and Legionella pneumophila in 1756 patients presenting with signs and symptoms of CAP at 12 medical centres in Asia, using standardised laboratory techniques and interpretation criteria in all participating centres. Methods: Diagnosis of current infection was based on significant changes in antibody titer or persisting high antibody titers, together with the presence of bacterial DNA in respiratory secretions, in the case of M. pneumoniae and C . pneumoniae infections, or bacterial antigen in urine, in the case of L. pneumophila serogroup 1 infection. Results: Using these criteria, results from 1374 patients with paired sera showed that, overall, 23.5% of CAP cases were associated with infection with atypical respiratory pathogens, with M. pneumoniae , C. pneumoniae , and L . pneumophila being found in 12.2%, 4.7%, and 6.6% of cases, respectively. Persisting high antibody titers indicative of past exposure to M. pneumoniae , C. pneumoniae , and L. pneumophila were seen in 10.2%, 4.8%, and 18.9% of patients, respectively. Conclusion: These data reflect the overall high prevalence of these atypical pathogens among Asian patients with CAP. |
| Databáze: | OpenAIRE |
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