Serum Ferritin Level Remains a Reliable Marker of Bone Marrow Iron Stores Evaluated by Histomorphometry in Hemodialysis Patients
| Autor: | Fellype C. Barreto, Sergio Antonio Draibe, Maria Regina Regis da Silva, Lillian Andrade da Rocha, Maria Eugênia Fernandes Canziani, Daniela V. Barreto, Cristiane Bitencourt Dias, Vanda Jorgetti, Luiz Antonio Ribeiro de Moura, Rosa M.A. Moysés, Aluizio B. Carvalho |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Epidemiology Anemia Iron Cell Count Hematocrit Critical Care and Intensive Care Medicine Gastroenterology Hemoglobins Bone Marrow Predictive Value of Tests Renal Dialysis Internal medicine medicine Humans chemistry.chemical_classification Transplantation Anemia Iron-Deficiency Staining and Labeling medicine.diagnostic_test biology Histocytochemistry Transferrin saturation business.industry C-reactive protein Transferrin Reproducibility of Results Bone Marrow Examination Middle Aged medicine.disease Bone marrow examination C-Reactive Protein Cross-Sectional Studies medicine.anatomical_structure chemistry Nephrology Ferritins biology.protein Kidney Failure Chronic Female Bone marrow Hemoglobin business Dialysis Biomarkers |
| Zdroj: | Clinical Journal of the American Society of Nephrology. 4:105-109 |
| ISSN: | 1555-9041 |
| DOI: | 10.2215/cjn.01630408 |
| Popis: | Background and objectives: As well as being a marker of body iron stores, serum ferritin (sFerritin) has also been shown to be a marker of inflammation in hemodialysis (HD) patients. The aim of this study was to analyze whether sFerritin is a reliable marker of the iron stores present in bone marrow of HD patients. Design: Histomorphometric analysis of stored transiliac bone biopsies was used to assess iron stores by determining the number of iron-stained cells per square millimeter of bone marrow. Results: In 96 patients, the laboratory parameters were hemoglobin = 11.3 ± 1.6 g/dl, hematocrit = 34.3 ± 5%, sFerritin = 609 ± 305 ng/ml, transferrin saturation = 32.7 ± 22.5%, and C-reactive protein (CRP) = 0.9 ± 1.4 mg/dl. sFerritin correlated significantly with CRP, bone marrow iron, and time on HD treatment (P = 0.006, 0.001, and 0.048, respectively). The independent determinants of sFerritin were CRP (β-coef = 0.26; 95% CI = 24.6 to 132.3) and bone marrow iron (β-coef = 0.32; 95% CI = 0.54 to 2.09). Bone marrow iron was higher in patients with sFerritin >500 ng/ml than in those with sFerritin ≤500 ng/ml. In the group of patients with sFerritin ≤500 ng/ml, the independent determinant of sFerritin was bone marrow iron (β-coef = 0.48, 95% CI = 0.48 to 1.78), but in the group of patients with sFerritin >500 ng/ml, no independent determinant of sFerritin was found. Conclusions: sFerritin adequately reflects iron stores in bone marrow of HD patients. |
| Databáze: | OpenAIRE |
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