STRAIN DIFFERENCES IN LOCAL HEMORRHAGIC RESPONSE (SHWARTZMAN-LIKE REACTION) OF MICE TO A SINGLE INTRADERMAL INJECTION OF BACTERIAL POLYSACCHARIDES
| Autor: | Norman H. Smith, Margaret G. Kelly, Isidore Wodinsky, David P. Rall |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1957 |
| Předmět: |
Pathology
medicine.medical_specialty Shwartzman phenomenon Necrosis Injections Intradermal Immunology Naphthalenes Polysaccharide Skin Diseases Article Mice Inbred strain Polysaccharides medicine Hypersensitivity Immunology and Allergy Animals Intradermal injection Skin chemistry.chemical_classification Anticoagulant drug Strain (chemistry) integumentary system business.industry Polysaccharides Bacterial Bacterial polysaccharide medicine.disease chemistry Injections Intravenous Rabbits medicine.symptom business Shwartzman Phenomenon |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| Popis: | A survey of inbred strains of mice was made to determine whether the phenomenon of dermal hemorrhagic necrosis, as described in rabbits by Shwartzman, could be elicited in mice by bacterial polysaccharide preparations of demonstrated activity in rabbits. The polysaccharide preparations used were obtained from cultures of S. marcescens, S. typhosa, Ps. aeruginosa, and H. pertussis. Ten of the strains tested were unreactive. Three strains of mice and one F1 hybrid subline developed a hemorrhagic lesion at the site of injection of a single, relatively high intradermal dose of polysaccharide. Some increase in incidence of hemorrhagic lesions was obtained when the intradermal dose was followed in 24 hours by an intravenous injection. In the gross and microscopically, the skin lesion produced in mice resembled the Shwartzman reaction in rabbits. An adrenergic blocking agent, SY-28, and an anticoagulant drug, coumadin, both of which block the dermal Shwartzman reaction in rabbits, also blocked the hemorrhagic skin reaction in mice. |
| Databáze: | OpenAIRE |
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