The SUVmax (maximum standardized uptake value for F-18 fluorodeoxyglucose) and serum squamous cell carcinoma antigen (SCC-ag) function as prognostic biomarkers in patients with primary cervical cancer
| Autor: | Ling Ling Pan, Min Zhou, Zhi Feng Yao, Jing Yi Cheng, Ying Jian Zhang |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Oncology Cancer Research medicine.medical_specialty Uterine Cervical Neoplasms Standardized uptake value Multimodal Imaging Gastroenterology Metastasis Young Adult Antigens Neoplasm Fluorodeoxyglucose F18 Internal medicine Biomarkers Tumor medicine Humans Survival rate Cervix Lymph node Serpins Aged Neoplasm Staging Cervical cancer Fluorodeoxyglucose business.industry General Medicine Middle Aged Prognosis medicine.disease Primary tumor Survival Rate stomatognathic diseases medicine.anatomical_structure Lymphatic Metastasis Positron-Emission Tomography Multivariate Analysis Carcinoma Squamous Cell Female Neoplasm Recurrence Local Tomography X-Ray Computed business medicine.drug |
| Zdroj: | Journal of Cancer Research and Clinical Oncology. 138:239-246 |
| ISSN: | 1432-1335 0171-5216 |
| DOI: | 10.1007/s00432-011-1092-z |
| Popis: | The aim of the present study was to investigate the prognostic significance of FDG uptake measured as maximum standardized uptake value (SUVmax) in primary tumor by positron emission tomography with fluorine-18-fluorodeoxyglucose (FDG-PET/CT) and pretreatment serum squamous cell carcinoma antigen (SCC-ag) in patients with cervical cancer. 82 consecutive patients with biopsy-proven cervical cancer who had PET/CT before any treatment were enrolled in this study. The SUVmax of the primary cervical tumor mass was obtained and compared with pretreatment SCC-ag and pathological prognostic factors after the initial treatment. There was significant correlation between the SUVmax of the primary tumor and tumor maximum size (p = 0.0024). The serum SCC-ag had a statistically significant association with lymph node metastasis (p = 0.0373), although there was no correlation between the SUVmax of the primary tumor and the serum SCC-ag (r 2 = −0.57). The higher SUVmax of primary tumor (≥11.2) plus pelvic lymph node (PLN) metastasis and higher SUVmax plus higher serum SCC-ag (≥6.4 ng/nl) were two most significant variables that predicted worse prognosis (p = 0.0099 and p = 0.0020, respectively). Higher pretreatment SUVmax of primary tumor indicated worse prognosis, and the prognosis of patients with higher pretreatment SUVmax plus PLN metastasis was even worse both in patients of squamous cell carcinoma (SCC) and non-SCC of cervix. As for patients with SCC of cervix, higher pretreatment serum SCC-ag not only predicted worse prognosis but also predicted disease recurrence in the posttreatment surveillance. |
| Databáze: | OpenAIRE |
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