Extremely Rapid Spread of Human Immunodeficiency Virus Type 1 BF Recombinants in Argentina
| Autor: | Edward C. Holmes, Carlos Rocco, Andrea Mangano, Paula C. Aulicino, Luisa Sen |
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| Rok vydání: | 2007 |
| Předmět: |
Demographic history
Molecular Sequence Data Immunology Population Argentina HIV Infections Genes env Microbiology Virus Disease Outbreaks Virology Genes vpu Humans Doubling time Sida education Phylogeny Genetic diversity education.field_of_study biology Bayes Theorem biology.organism_classification Genetic Diversity and Evolution Insect Science Lentivirus HIV-1 Viral disease |
| Zdroj: | Journal of Virology. 81:427-429 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.01403-06 |
| Popis: | The epidemic of human immunodeficiency virus type 1 (HIV-1) in Argentina is distinctive in that many infections are caused by subtype BF recombinant viruses. To determine their demographic history, we estimated the evolutionary rate, mode of population growth, and age of genetic diversity among 40 BF vpu sequences. This revealed one of the highest substitution rates reported for HIV-1, at 10.793 × 10 −3 substitutions per site per year, and a very rapid rate of population growth, with an initial mean epidemic doubling time of 3.72 months. This rapid population growth is compatible with an elevated fitness for subtype BF compared to that for “pure” B and F viruses. |
| Databáze: | OpenAIRE |
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