Photo- and pH- Dual-Responsive β-Cyclodextrin-Based Supramolecular Prodrug Complex Self-Assemblies for Programmed Drug Delivery

Autor:	Cai Ping Liu, Long-Hai Zhuo, Huaitian Bu, Xin Song, Yang Bai, Wei Tian
Rok vydání:	2018
Předmět:	Cell Survival Ultraviolet Rays Supramolecular chemistry 02 engineering and technology 010402 general chemistry 01 natural sciences Biochemistry Micelle Drug Delivery Systems Neoplasms Amphiphile Humans Static light scattering Prodrugs chemistry.chemical_classification Antibiotics Antineoplastic Cyclodextrin Chemistry Vesicle Organic Chemistry beta-Cyclodextrins General Chemistry Prodrug Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Combinatorial chemistry 0104 chemical sciences Drug Liberation Doxorubicin Delayed-Action Preparations Drug delivery MCF-7 Cells 0210 nano-technology Azo Compounds
Zdroj:	Chemistry, an Asian journal. 13(24)
ISSN:	1861-471X
Popis:	Despite the fact that progress has been made in the application of supramolecular prodrug self-assemblies to enhance the functionality of drug-delivery systems, corresponding research on multi-responsive supramolecular prodrug self-assemblies for programmed drug delivery is still limited. In this paper, the synthesis and self-assembly behavior of supramolecular prodrug complexes (SPCs) with β-cyclodextrin-acylhydrazone-doxorubicin (β-CD-hydrazone-DOX) and the targeting of azobenzene-terminated poly[2-(dimethylamino)ethyl methacrylate] (Azo-PDMA-FA) as a building block were investigated. The obtained SPCs could also form self-assemblies on the basis of their amphiphilic nature. Next, SPC-based multi-compartment vesicles and complex micelles, which were confirmed by transmission electron microscopy and dynamic/static light scattering, were obtained with good reversibility under alternative visible light or UV irradiation. Furthermore, three-stage programmed drug-delivery behavior was observed from dual-responsive SPC-based self-assemblies by utilizing UV and pH stimuli. Specifically, the SPCs first self-assembled into multicompartmental vesicles, which was accompanied by a slow release of DOX. Next, UV-light irradiation induced the dissociation of β-CD/Azo, which led to morphology transition and a slight increase in the rate of release of DOX. Upon transferring the self-assemblies to phosphate-buffer solution (pH 5.0), the release rates increased notably as a result of the broken acylhydrazone bond. Finally, basic cell experiments further demonstrated that the SPC-based self-assemblies could be internalized into cancer cells, which suggests their promise for applications in cancer therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec5a0d1bd9c30e16130c7574019b177 https://pubmed.ncbi.nlm.nih.gov/30311448 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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