d-amphetamine facilitation of Morris water task performance is blocked by eticlopride and correlated with increased dopamine synthesis in the prefrontal cortex
| Autor: | Scott B Phillips, Derek D. Mace, Russell W. Brown, Philipp J. Kraemer, Michael T. Bardo |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Dextroamphetamine Dopamine Prefrontal Cortex Rats Sprague-Dawley Behavioral Neuroscience chemistry.chemical_compound Eticlopride Cortex (anatomy) Salicylamides medicine Animals Maze Learning Amphetamine Prefrontal cortex Neurotransmitter Dopaminergic Dihydroxyphenylalanine Rats medicine.anatomical_structure chemistry Facilitation Dopamine Antagonists Central Nervous System Stimulants Psychology Neuroscience medicine.drug |
| Zdroj: | Behavioural Brain Research. 114:135-143 |
| ISSN: | 0166-4328 |
| DOI: | 10.1016/s0166-4328(00)00225-4 |
| Popis: | The effect of posttraining D-amphetamine on Morris water task (MWT) performance was analyzed in this study by training rats using a single training trial per day procedure. In addition to acquisition latency, learning was assessed by a probe trial given 24 h after the last training trial. Rats given immediate post-trial D-amphetamine demonstrated improved performance over saline rats on both acquisition and the probe trial. An analysis of the mechanisms underlying facilitation revealed that eticlopride (a D2 antagonist) blocked D-amphetamine's facilitatory effects on the probe trial and dopamine synthesis was increased in the medial prefrontal cortex in the D-amphetamine group relative to controls. These results show that chronic administration of posttraining D-amphetamine facilitated MWT performance, and this facilitation may be mediated by the dopaminergic system and dopamine synthesis in the prefrontal cortex. |
| Databáze: | OpenAIRE |
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